The study presents the results of the study of adaptive reactions and adaptive potential of the circulatory system of patients with vibration disease and chronic bilateral sensorineural hearing loss.

Biological age and rates of aging of patients with vibration disease and bilateral sensorineural hearing loss were studied. The biological age of patients exceeded the calendar age by an average of 7.36±0.36 years and the proper biological age by 10.79±0.72 years. The rate of biological aging of the examined patients was 1.14±0.08 times higher than the rate of aging of their healthy peers.

Aim. To provide data on the diagnostic and prognostic value of questionnaire survey for post-COVID-19 syndrome during screening and regular medical check-ups of employees, as well as preventive medical examinations.Material and methods. This single-center cross-sectional comparative study involved 1120 people (92,1% of the general population — all employees of the organization), including 195 men (67,3% of the general population) and 925 women (79,5% of the general population). All participants filled out the post-COVID-19 syndrome (PS) detection questionnaire, the Hospital Anxiety and Depression Scale and the QAA-25p Adherence Assessment Questionnaire. Potential adherence to treatment was calculated using the SCOPA software. Statistical processing was performed using tools adapted for medical and biomedical research (Python language; Sklearn, NumPy, Pandas libraries) and Statistica 6.13 (StatSoft Inc., USA).Results. As a result, 47% of respondents noted at least one symptom that reduces the quality of life and/or performance efficacy. In all subsamples, women reported symptoms more frequently than men. The most informative indicators associated with post-COVID-19 syndrome are age (Mann-Whitney U test, p=0,042), number of PS symptoms (Mann-Whitney U test, p=0,001), severity of PS symptom (Mann-Whitney U test, p= 0,004) and adherence to health care (Kruskal-Wallis H test, p=0,021). An increased level of anxiety is associated with all the analyzed symptoms, depression level with 6 symptoms, age with 5 symptoms, insufficient compliance with 3 symptoms.Conclusion. PS questionnaire should be included in a comprehensive survey program of persons undergoing medical examinations. It is necessary to develop algorithms for the treatment and diagnosis of patients that take into account the number and severity of individual symptoms separately for men and women with consideration to their COVID-19 epidemiological status, as well as age and markers of anxiety, depression, and adherence to treatment.

Introduction: The problem of practical application of recommended methods of processing ambient air pollutant concentra­ tions below the limit of detection in chemical analysis raises uncertainties in human health risk assessment. The Federal Clean Air Project has increased legal significance of the latter and the relevance of interdepartmental cooperation in air monitoring activities. Objective: To review methodological approaches to handling ambient air quality test results and to develop proposals for uncertainty reduction in human health risk assessment. Materials and methods: We analyzed ways of dealing with values of ambient air pollutant concentrations lying below the limit of quantification of various analytical chemistry methods proposed by the European Bureau for Integrated Pollution Preven­ tion and Control and Russian researchers. A human (population) health risk assessment was conducted based on air quality parameters obtained in 2020 within environmental and public health monitoring in the city of Omsk using average concentrations of airborne pollutants measured by different techniques in accordance with national guidelines R 2.1.10.1920–04. Results: Different approaches to processing air quality test results produced different average pollutant concentrations accounting for health risk values ranging from the acceptable level to that of concern. Our estimates showed that certain tech­ niques of quantitative chemical analysis of priority air contaminants are inappropriate for the purposes of human health risk assessment. Photometry, for instance, was found unacceptable for measuring ambient concentrations of formaldehyde to assess carcinogenic risks due to unreasonable overestimation of the latter. Conclusions: We have proposed criteria for selecting appropriate methods of air quality testing based on estimated values of the lower limit of quantification of chemicals and for optimizing procedures of processing test results for correct assessment of health risks and harmonization of interdepartmental approaches.

Aim. Develop a program to prevent health losses in adolescents with connective tissue dysplasia. Methods. Analyzed was the clinical data of 241 adolescents for the period 2006-2009, 113 adolescents formed the main group, 128 - the control group. The statistical rules and standards for determining the grouping signs and group boundaries on the basis of phenotypic and visceral traits of connective tissue dysplasia were taken into consideration. Results. The proposed program for prophylaxis of health loss provides the following stages: informational, analytical, and organizational-executive with an educational component along with curative and preventive measures. The proposed program of prophylaxis provides complete information on the health status of adolescents with connective tissue dysplasia, promotes the reduction of the frequency of progression of signs of dysplasia. Conclusion. The program provides an opportunity to optimize the existing approaches to identifying and assessing factors that influence health, and promote more efficient use of the available resources in the education and healthcare systems.