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Keywords: 2-hydrazino-3,4,5,6-tetrahydro-2H-azepine, 2,3-dioxopyrrolo[2,1-a]isoquinolines, 3,3-dimethyl-1-(1,2,4-triazolo[4,5-a]azepan-8-ylcarbonylmethylideno)-1,2,3,4-tetrahydroisoquinolines, opening of the dioxopyrroline ring.In previous work [1, 2], we showed that the reaction of 2,3-dioxopyrrolo[2,1-a]isoquinolines with several dinucleophiles might proceed with opening of the lactam bond and concurrent heterocyclization. The reactions of these compounds with cyclic hydrazidines have not yet been reported. In a continuation of a study of the chemical properties of these compounds, we found that dioxopyrrolines 1a,1b readily undergo opening of the pyrroline ring upon moderate heating in benzene to give enamino ketones 2a,b.This method was used to synthesize various compounds with potential biological activity. In the case R = H, the compounds obtained are enamino ketones, which are capable of further transformations.The 1 H NMR spectra were taken on a Bruker-300 spectrometer at 300 MHz in CDCl 3 with HMDS as the internal standard. The IR spectra were taken on a Specord M-80 spectrometer for vaseline mulls. The electron impact mass spectra were taken on an MAT-311 at 70 eV.

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