Objective: the article presents the results of a study of the neuropsychological profile of cognitive functions in patients with endogenous depression, in the structure of which overvalued formations are revealed. The study of cognitive processes in patients with such disorders will help determine prognostic criteria and contribute to the development of optimal recommendations for personalized therapy of these conditions.The aim of the study was to determine the characteristics of cognitive functioning and its dynamics in patients with endogenous depression with overvalued formations.Patients and methods: using clinical-psychometric, neuropsychological, pathopsychological methods, 45 patients were examined. 26 men (average age 28.7 ± 7.3) and 19 women (average age 34 ± 8.6) had a manifest or repeated depressive state within the framework of an affective disease (F31-34 according to ICD-10) with the phenomenon of overvalued formations. The control group was represented by a similar in number, comparable in terms of sex and age group of patients (45 patients) with a depressive state that forms within the affective phase (F31-34 according to ICD-10), without overvalued formations.Results: in the course of the work, differences were found in the structure of the neurocognitive deficit of endogenous depression with overvalued formations from that of depressions without the phenomenon of overvalued formations. As a result of neuropsychological screening of patients in the group of endogenous depressions with overvalued formations, data were obtained on dysfunction of the anterior sections of the predominantly left hemisphere and related regulatory deficiency. Conclusions: patients with endogenous depressions occurring with a predominance of overvalued formations in the clinical, a neurocognitive deficiency of the regulatory domain is characteristic, which is different from that in depressions without the phenomenon of overvalued formations.