Atrial fibrillation (AF) is the most common arrhythmia in the adult population, and the number of patients with this arrhythmia will increase in the future. As a result, the number of patients taking anticoagulants (ACs), which are considered "high alert medication" is constantly increasing. The aim. To highlight the problems of ACs use in patients with non-valvular AF in real clinical practice, to consider the therapy safety and treatment adherence. The main body. Approval of new oral ACs has provided more options to clinicians and patients, but even with their use, errors are possible that increase the risk of bleeding. Mistakes can be made by both patients and doctors. The introduction of training as a mandatory element in the complex therapy of AF helps to reduce the number of errors that the patient could make. The clinical condition, the availability of monitoring and the patient's wishes for treatment may change over time, and this may lead to the need to switch the AC, which is potentially dangerous in terms of side effects. The risk of bleeding increases regardless of the direction of change of AC - the very fact of transition is important. Doctor`s errors play a significant role in the risk increase at this stage, and it is important to raise their awareness of the rules for the ACs switch to avoid bleeding. The article presents the rules of transition from one oral AC to another, following which doctors will minimize the risk of side effects in clinical practice. Conclusion. The use of AC for patients with AF is life-saving, but if used improperly, life-threatening side effects can occur. According to research, in many cases, the development of the latter could be prevented primarily through patient education and the proper doctor training.

The purpose of the work. To identify the factors that determine the relationship between adherence to treatment and QoL in the elderly with CHF on the background of AH and CKD, and to assess the possibilities of using the obtained data in clinical practice.Material and methods. The study included 93 patients from 60 to 74 years old with CHF on the background of AH and CKD. Clinical and laboratory studies, a questionnaire regarding the presence of side effects, an assessment of the quality of life using the Minnesota questionnaire and adherence to treatment according to the Morisky-Green scale were used in all the patients.Results. Correlation analysis revealed the following relationships: for adherence to QoL - -0.57 (-0.69; -0.42); for systolic blood pressure with QoL - 0.46 (0.28; 0.61) and with adherence - -0.35 (-0.52; -0.16;); for the creatinine with QоL - 0.35 (0.16; 0.52) and with adherence - -0.3 (- 0.47; -0.1); for EPI GFR with QoL - -0.46 (-0.61; -0.28) and with adherence - 0.33 (0.14; 0.5); for the 6-minute walk test with QoL - -0.65 (-0.78; -0.52) and with adherence - 0.49 (0.32; 0.63). For all identified relationships p is <0.05.Conclusions. In the elderly with CHF on the background of AH and CKD, correlations of moderate strength were found between the clinical and laboratory parameters of these diseases, QoL, and adherence to treatment. Identified pathogenetic links can be used to explain to the patient the need to follow the doctor's recommendations. A change in QoL can serve as a marker showing that some revising is needed in a patients’ treatment.