The article presents the history of World Kidney Day 20062023. The World Kidney Day, which started in 2006, has become an annual successful initiative of the International Society of Nephrologists, the International Federation of Kidney Foundations to inform the world community and politicians, healthcare about the importance of kidneys for general health, to raise awareness about the significance and consequences of congenital, hereditary and acquired kidney diseases, chronic kidney disease, to adopt a strategy, aimed at reducing the frequency, severity and impact of kidney diseases on health and life. The global nature of the problem of kidney disease in children and adults is evidenced by the fact that in 2011 the Political Declaration on Non-infectious diseases, approved at the summit of the World Healthcare Organization, included kidney disease under paragraph 19. Chronic kidney disease is the 6th cause of death in the world. The annual campaign of World Kidney Day 20062023 poses medical and socio-economic problems of global importance and reminds that kidney diseases affecting children and adults are common, dangerous and curable. World Kidney Day 2023, under the motto: Kidney Health for all preparedness for the unexpected, support for the vulnerable discusses the impact of disasters, in particular the COVID-19 pandemic, on the provision of specialized nephrological care to the population and its resources around the world.

Chronic kidney disease (CKD) in children is a global problem worldwide. The article discusses the problem of stratification of CKD severity according to the classifications of the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative (NKF-K / DOQI) (2002) and Kidney Disease Improving Global Outcomes (KDIGO) (2012) in pediatric patients. There are limitations in assessing severity of CKD stages C1-5 according to NKF-K / DOQI (2002) and KDIGO (2012) in children under 2 years of age who have a low glomerular filtration rate in contrast to adults. The stratification of the severity of stages 1-5 of CKD, cardiovascular complications and renal prognosis in children and adolescents according to the classifications NKF-K / DOQI (2002) [3] and KDIGO (2012) [14] are discussed. In adult patients with CKD, there is a compelling case for identifying of C3a and C3b sub stages in 3 stages of CKD according to KDIGO (2012) was that renal and cardiovascular prognosis are different with GFR 45-59 ml/min/1.73 m 2and GFR 30-44 ml/min/1.73 m 2 . The prognosis of the risk of developing cardiovascular diseases and complications for stages C2-5 in accordance with the KDIGO classification (2012) in children and adults differ. As follows from the publications, children with CKD in the pre-dialysis stages C2-4 form a high-risk group, with C4-5 on dialysis a group of very high risk of complications associated with cardiovascular pathology. Cardiovascular complications account for more than 30 % of all deaths of pediatric patients with CKD C4-5 on dialysis. The arguments justifying the allocation of CKD stages C1-5 in children under 2 years of age in accordance with the classification of NKF-K/DOQI (2002) are presented.

РЕФЕРАТ В статье представлен обзор литературы по клиническим, морфологическим, молекулярно-генетическим особенностям MYH9-ассоциированного синдрома Epstein, протекающего с макротромбоцитопенией, нейросенсорной тугоухостью, нефропатией. Обсуждены клинико-генетические варианты, особенности течения, лечения и прогноза MYH9ассоциированного синдрома Epstein у детей. Описано клиническое наблюдение MYH9-ассоциированного синдрома Эпштейна у мальчика 8 лет.

Chronic kidney disease in pediatric and adult patients is an overarching global problem. Stratification of chronic kidney disease C1–5 severity by classifications of the National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative (NKF-K/DOQI) (2002) and Kidney Disease: Improving Global Outcomes (KDIGO) (2012) carried out in pediatric patients over the age of 2 years old, taking into account the low glomerular filtration rate at the age of 0 to 2 years. Differences were found in the prognosis of cardiovascular complications and the progression of renal failure in adult patients with chronic kidney disease at stages С3а and C3b according to KDIGO (2012). The literature data demonstrate different risks of cardiovascular complications and progression of renal functions by stages of chronic kidney disease in accordance with the NKF-K/DOQI (2002) and KDIGO (2012) classifications in pediatric patients. The results indicate that children with chronic kidney disease in the pre-dialysis stages C2–4 form a high-risk group, while those on C4–5 dialysis form a group of very high risk of cardiovascular complications.