Background. Phylloid tumors are a fairly rare pathology (about 0.3–0.5 % of all breast tumors), which is why there is no single protocol for the treatment of this pathology. Also, due to the lack of data and the rare occurrence, it is difficult to diagnose and choose the final management tactics of the patient. Phylloid tumors can be benign, borderline, and malignant neoplasms, which also complicates the treatment process. The final decision on the choice of patient management tactics can be made only after receiving the results of a planned pathomorphological examination.Materials and methods. In this article, we will discuss the results of major retrospective studies, including data on epidemiology, etiology, diagnostic approach, strategies and results of treatment of phylloid breast tumors, as well as present data on patients treated at the Russian Scientific Center of Radiology of the Ministry of Health of the Russian Federation for the period from January 2010 to February 2021.Results. The main methods of instrumental diagnosis of phylloid tumors are mammography, ultrasound and MRI. Morphological examination is important in making a diagnosis. Fine-needle biopsy often does not allow establishing an accurate diagnosis, and therefore the main method of diagnosis remains pathohistological examination. The main method of treatment of phylloid tumors remains surgical, where, depending on the trepan biopsy, the question of the feasibility of performing an organ-preserving operation is decided.Conclusion. Phylloid tumors are a rare type of breast neoplasm, which is the reason for the relatively small amount of scientific research that addresses this particular problem.

Relevance. Currently, there is no definite answer to the question of the cause of breast cancer, since it is a systemic and multifactorial disease. Given that the number of aesthetic operations on the mammary glands using endoprostheses only increases every year, new cases of detection of malignant diseases do not decrease. Some researchers are beginning to speak out about the possible connection of augmentation mammoplasty in the anamnesis with the subsequent occurrence of breast cancer due to inadequate clinical and instrumental examination and ignoring some of its components (for example, the mammographic examination). Introduction. Taking into account the analysis of the literature and the presented clinical examples, the possible reasons for the connection of augmentation mammoplasty in the anamnesis with the subsequent detection of a malignant neoplasm are analyzed. Materials and methods. We analyzed domestic and foreign literature and described two clinical examples with authentic documentation based on the results of the examination and treatment. The article describes in detail the schemes of drug treatment and descriptions of the results of morphological examination of the surgical material. The types and results of surgical treatment with reliable photos are also presented. Results. Given the complexity of the diagnostic stage in patients with breast endoprosthesis in the described clinical examples, family history collected in sufficient detail, cytogenetic studies conducted, we should talk about the likely underdiagnosis during preventive examinations. Conclusion. The multifactorial and systematic nature of such a disease as breast cancer suggests that perhaps an intensive increase in the detectability of the above-mentioned against the background of previously performed aesthetic surgery would be the simplest solution to the problem. In this category of patients, anamnesis should be collected in more detail and carefully, and the entire complex of clinical and instrumental examinations, including mammography, magnetic resonance and ultrasound examinations, should be performed in order to fully diagnose and develop further patient management tactics.

We performed comparative analysis of the efficiency of planar scintigraphy and SPECT-CT in the localization of sentinel lymph nodes (SLN) in the early stages of breast cancer in 50 patients. The true amount of SLN by lymphoscintigraphy was detected in 48% of observations, clear visualization was achieved in 78% of cases. There was no significant correlation between the efficiency of the planar study and the body mass index of the patients. The SPECT-CT analysis of regional lymphatic drainage of the mammary gland allowed to determine both the exact localization and the number of SLN in all patients included in the study. Comparison of SLN size and structure with histology results revealed no reliable association between CT anatomy and the presence of metastases in the lymph nodes.

Background. Currently, there are several forms of breast cancer (BC): nodular, diffuse, edematous-infiltrative, mastitis-like form, as well as Paget’s cancer. A special form of BC is the hidden or occult form. Taking into account the analysis of methods for the diagnosis and treatment of occult BC, it is important that this form of the disease is detected at a later stage. It includes axillary lymphadenopathy and histologically appears to be a metastatic lesion of the lymph nodes from undetectable invasive BC.Materials and methods. We conducted a thorough analysis of domestic and foreign literature and described two clinical examples with authentic documentation of the results of the examination and treatment. The article describes in detail the schemes of drug treatment and descriptions of the results of morphological examination of the surgical material.Results. Given the complexity of the diagnostic stage, the clinical form of the course of diseases, the described clinical examples can be attributed specifically to the occult form of BC. An important and determining factor in treatment is the diagnostic stage using all possible methods, including positron emission tomography–computed tomography, breast magnetic resonance imaging and trepan-biopsy of regional lymph nodes, followed by the determination of the molecular biological subtype of the tumor.Conclusions. In this article, the presented data confirm the general statement about the uniqueness of this disease, which requires a more detailed and multidisciplinary approach at the stage of diagnosis and determination of treatment tactics.