Introduction: Detection and treatment of chronic endometritis (CE) is clinically significant, though involves intrauterine intervention to collect endometrium. The aim: To estimate the possibility to use fertility α2-microglobulin (FAMG) as the marker of the high risk for CE. Materials and methods: 70 women with CE who were planning pregnancy were tested for FAMG in menstrual blood. 40 of them received treatment of CE. The other 30 women refused from the proposed treatment. The control group involved 30 women who had neither CE nor luteal phase deficiency (LPD). Additional group (20 women) had LPD without CE. Results: The decrease of FAMG by 2.4 times was noted in women with CE (16.3 ± 3.9 μg/ml against 39.8 ± 8.3 μg/ml in the controls). In LPD the index was 5.6 times lower. After treatment the level of FAMG was increasing. Conclusions: The decrease of the amount of FAMG in menstrual blood is specific for women both with CE and LPD. Detection of abnormally low rates of FAMG in all women with CE enables, with the exception of absolute hypoprogesteronemia and LPD, using it as a simple method of estimation of the functional state of endometrium. Its application can be very useful both for non-invasive diagnosis of CE and subsequent evaluation of treatment of this pathology.

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The aim: To determine the serum FAMG in the I and II trimester of pregnancy in women with a past history of chronic endometritis, and to clarify its impact on the development of pathology of pregnancy. Materials and methods: The level of FAMG was determined at 6-8 and 16-18 weeks of gestation in 135 pregnant women with a past history of chronic endometritis, who received treatment of chronic endometritis at the stage of pregravid preparation and 168 women who became pregnant without its prior treatment. The dependence of the development of pre-eclampsia on the level of FAMG at the early stages of pregnancy has been evaluated. Results: At 6-8 weeks of pregnancy, the level of FAMG in women with a past history of chronic endometritis was 20.6% lower (122.4 ± 7.6 ng/ml) compared to the control group. In FAMG of 90.3 ± 4.3 ng/ml at 6-8 weeks of gestation, spontaneous abortion occurred in 100% of cases within the next 2 weeks. FAMG lower than 122,1 ± 3,0 ng/ml can be the predisposing factor for the development of pre-eclampsia. Conclusions: Reduced FAMG in the beginning of pregnancy in women with untreated chronic endometritis in the past history increases the incidence of miscarriages at the early stages by 2.6 times, and by 1.8 times the probability of preeclampsia development. Treatment of chronic endometritis at the stage of pregravid preparation promotes the increase of FAMG by 24,6% compared to untreated women that reduces the probability of complications during the subsequent course of pregnancy.

Introduction. In the structure of the causes of preterm delivery among patients who become pregnant through in vitro fertilization (IVF), immunological problems rank one of the leading places. Purpose: To identify alterations in cellular and humoral immunity in women with a history of infertility, who became pregnant through IVF, and who was at risk of preterm delivery. Materials and methods. The test group consisted of 37 women who became pregnant through IVF and manifested prognostic signs indicating a high risk of preterm delivery in the future. These women refused taking preventive therapy to reduce the risks of preterm birth. The control group (healthy pregnant women) included 20 women with physiological course of pregnancy. The indicators characterizing cellular and humoral components of immunity were investigated. Results and discussion. The women of the test group demonstrated changes in both cellular (decreased blood level of total T-lymphocytes, decreased level of T-helpers, fall in the of B-lymphocyte content) and humoral (decreased IgA content, decreased immunoregulatory index and tendency toward the lowering of immunoglobulin index, decreased concentration of circulating immune complexes) immunity. Conclusions: The changes in cellular and humoral immunity in pregnant women who undergoing IVF and were at risk of preterm delivery but refused preventive therapy have been manifested by decreased blood level of total T-lymphocytes, decreased level of T-helpers, considerable lowering in B-lymphocytes, and fall in Ig and IgG content). The results point out the progression of immunosuppression characteristic of the pregnancy course in general.

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