Treatment of hypervascular formations is challenging surgery. The solution of this problem is due to use a multidisciplinary approach, involving complex endovascular and surgical treatments. Patho-morphological study of remote hypervascular formations in treatment was carried out. That treatment consisted of an endovascular embolotherapy and an endovasal sclerotherapy in various combinations. The embolization of blood vessels leads to a complete reduction of blood flow in the formation area, the development of diffuse inflammatory infiltration in the background on tissue ischemia. In the future, developing ischemic necrosis fol-lowed by scarring of tissue surrounding the vascular formation. Sclerotherapy causes damage to the vascular endothelium with fibrin formation and hemolysis of red blood cells in the lumen of the veins. Moreover, there are a significant fibrosis, hyalinosis and inflammatory reaction of the tissues surrounding the vessels. Further development of this process leads to a final sclerosis and fibrotic scarring of the surrounding tissues. The combi-nation of endovascular embolization and sclerotherapy allows to achieve a reduction of blood flow in the arterial vascular malformation department and to cause a tissue fibrosis in the cavernous malformations. Endovascular therapy reduces the risk of bleeding in surgery and develops the capacity of radical treatment.