Aim. Assessment of risk of breast cancer secondary to earlier breast surgery for benign disease.Methods. The initial sample group of breast cancer included 295 patients who were followed up for 2006-2010. The final sample group of breast cancer (for primary analysis) was formed from this group and included 204 patients in order to provide accurate comparison with the control group on factors affecting the breast surgery probability for benign processes for life and on the lifetime risk for breast cancer. The control group included 1141 patients. The rate of surgical interventions for benign breast diseases was compared in the breast cancer group for primary analysis and the control group.Results. The rate of surgical interventions was significantly higher in breast cancer patients: (7.35 vs. 3.94% in the control group): odds ratio for breast cancer patients was 1.137; 95% confidence interval 0.981-1.318 (p=0.03). Duration of the gap between the initial surgical and subsequent development of breast cancer on operated side was 20.05±11.373 years (variation range - 8 to 54 years).Conclusion. Performed breast surgery might increase the risk of future developing breast cancer; however, a long-term study is needed to confirm these data.

Aim. Development and evaluation of the diagnostic value of techniques for quantitative analysis of masses on mammographic images satisfying the requirements of categories 2-4 in BIRADS (Breast Imaging Reporting And Data System - the system for classification and description of breast imaging results of the American College of Radiology).Methods. Images of 375 focal lesions revealed on mammography (211 malignant and 164 benign, all were verified morphologically), satisfying the criteria 2-4 according to BIRADS classification, were analyzed. Mathematical processing was performed using the MammCheck 1.15 software package developed by authors, which uploads the obtained images. Contour, segments of area, peripheral outlines, homogeneity and inner outlines indexes were calculated.Results.The statistical analysis of foci at standard mammography images of BIRADS 2-4 categories revealed no statistically significant difference in all four estimated parameters. When using tomosynthesis images, statistically significant difference was discovered in the outline index in the groups of benign and malignant foci (mean ± standard deviation: 1.73±1.11 vs. 3.11±2.02, respectively, pConclusion. Outline analysis of mammograms, including those obtained using tomosynthesis, does not provide the necessary level of specificity for the differential diagnosis of benign and malignant microcalcifications and clusters.