In the course of well construction, deterioration of the natural reservoir properties of the formation is inevitable. A dense lowpermeability filter cake formed on the surface of the bottomhole formation zone at the stage of completion contributes to a decrease in the reservoir properties of the rock, and hence the productivity of the well. In addition, the cake can contribute to the plugging of structural elements such as the well screen or inflow control devices, thereby also having a negative impact on the flow rate. In most cases, the impossibility of achieving the required cleaning of the bottomhole zone during well completion in the future leads to the need to use expensive repeated operations and overhaul, chemical and mechanical methods of cleaning the bottomhole formation zone. The development of technologies for the complete removal of the formed filter cake from the borehole walls is a necessary task. The paper considers the water-based biopolymer solution of the primary opening of the productive formation, the component composition and its parameters are given. A method is described for studying the effect of breaker systems on a polymer-mineral filter cake under high-pressure conditions using filter press HT-HP, and a method for determining the dissolving capacity of individual components of the system (chelate and enzyme). Based on the results of this study, the optimal composition of the breaker of the enzyme-chelate base was selected, after the action of which the most complete destruction of the crust constituents was observed. The results were evaluated by comparing the dissolving power of calcium carbonate when exposed to different chelates. The enzyme alpha-amylase was used as a starch breaker. The efficiency of the composition was confirmed by the change in the filtration-capacitive properties of ceramic discs before and after processing in comparison with foreign analogues of breaker systems.