A brief review of the literature devoted to the rare eosin-filed granulomatous necrotizing vasculitis ChurgStrauss syndrome is given. Two clinical cases of this disease are presented from the personal practice of the authors. The complexity of diagnostics was emphasized; it contributed to the fact that the disease lasted for a long time under the guise of other nosologies which later turned out to be syndromes of vasculitis ChurgStrauss. When pulmonary infiltrates occur in patients with asthma with allergic rhinitis or rhinosinusopathy in combination with high eosinophilia of peripheral blood and neurologic symptoms, it is necessary to suspect the Churg-Strauss syndrome and conduct appropriate diagnostic measures.