Antimicrobial properties of nitrile complexes of transition metal salts were studied including the investigation of their activity in surfactants and mineral oil environments. Experiments of the polymeric complexes preparation by in-situ copolymerization of the nitrile polymers in the presence of transition metal salts and reactions of transition metal salts added to the ready polymers were performed. The dependence of the polymer complexes forming particularities on central metal atoms nature was determined.