Dupuytren’s disease is an acute and multifaceted problem that affects not only medicine but also psychology, social life, since a person who has lost the ability to perform his/her socially significant functions experiences moral and physical suffering. From the first description of Dupuytren’s disease to the present, questions of etiology, pathogenesis, classification, treatment methods, and features of the preventive measures of this disease remain debatable. Therefore, the main goal of the paper was to analyze the technology for predicting the functional state of the hand after surgical treatment of Dupuytren’s disease (contracture). The study was conducted at the Department of Hand Microsurgery of the Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan. The total number of patients under observation was 258, age 21-80 years. The research results were grouped into 6 combinations. It has been determined that three groups of factors affect the recovery degree: A (gender, age, examination period, severity); B (place of residence, physical and mental work, bad habits); C (surgeon's experience, types of operations, anaesthesia, section, skin plastic, reconstructive treatment, healing, etc.). It has been found that it is possible to achieve full restoration of the function of the wrist on the right hand in 67.5% of patients and on the left hand in 59.9% of patients in periods of more than one year.

BackgroundThe parameters that characterize the intricate water diffusion in tumors may also reveal their distinct pathology. Specifically, characterization of breast cancer could be aided by diffusion magnetic resonance.The present in vitro study aimed to discover connections between the NMR biexponential diffusion parameters [fast diffusion phase (DFDP ), slow diffusion phase (DSDP ), and spin population of fast diffusion phase (P1)] and the histological constituents of nonmalignant (control) and malignant human breast tissue. It also investigates whether the diffusion coefficients indicate tissue status.MethodsPost-surgical specimens of control (mastopathy and peritumoral tissues) and malignant human breast tissue were placed in an NMR spectrometer and diffusion sequences were applied. The resulting decay curves were analyzed by a biexponential model, and slow and fast diffusion parameters as well as percentage signal were identified. The same samples were also histologically examined and their percentage composition of several tissue constituents were measured: parenchyma (P), stroma (St), adipose tissue (AT), vessels (V) , pericellular edema (PCE), and perivascular edema (PVE). Correlations between the biexponential model parameters and tissue types were evaluated for different specimens. The effects of tissue composition on the biexponential model parameters, and the effects of histological and model parameters on cancer probability, were determined by non-linear regression.ResultsMeaningful relationships were found among the in vitro data. The dynamic parameters of water in breast tissue are stipulated by the histological constituents of the tissues (P, St, AT, PCE, and V). High coefficients of determination (R2) were obtained in the non-linear regression analysis: DFDP (R2 = 0.92), DSDP (R2 = 0.81), and P1(R2 = 0.93).In the cancer probability analysis, the informative value (R2) of the obtained equations of cancer probability in distinguishing tissue malignancy depended on the parameters input to the model. In order of increasing value, these equations were: cancer probability (P, St, AT, PCE, V) (R2 = 0.66), cancer probability (DFDP, DSDP)(R2 = 0.69), cancer probability (DFDP, DSDP, P1) (R2 = 0.85).ConclusionHistological tissue components are related to the diffusion biexponential model parameters. From these parameters, the relative probability of cancer in a given specimen can be determined with some certainty.

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Tuberculosis (TB) remains a major public health problem globally. Female genital tuberculosis (FGT) occurs mostly secondary to pulmonary tuberculosis, commonly by the haematogenous route. The main difficulties in the monitoring of treatment efficacy are connected with the use of the same technologies both in the diagnosis and cure estimation of FGT. Articles in tuberculosis journals rarely featured by equations. The aim of the present study was to elaborate new analytical approaches, in form of equation concerning FGT treatment efficacy identification. The general conclusion was created towards the RCSR (red cells sedimentation rate), PCR (polymerase chain reaction) and tuberculin skin-test, ultrasound and radial examinations: they are not reliable tools since both false-negative or false-positive cases were observed . Explanation of the mismatch of the most of identified alterations by means of ultrasound and radial examinations (CT and MRI) with the clinical status of women is explained by the prolonged maintenance of alterations caused by disease, up till several years after clinical recovery. Newly elaborated test based on 1 H-NMR (T 1 , T 2 ), relaxation times measurement in vitro being combined with the regression analysis models have a potential to assess the treatment efficacy of female genital tuberculosis in 70% of cases.