Abstract:Background -Periodontal diseases in adolescents are considered to be of current interest, since the incidence of these conditions tends to increase. Children being in the period of intensive growth are especially exposed to these conditions. Recent studies of molecular morphological disorders occurring in children with chronic catarrhal gingivitis indicate the need of immunocorrectors application in the complex treatment of patients with these disorders, that helps improve both periodontal tissue status and general health. Material and Methods -157 children aged 12-15 years were examined. Physical examination of a child included past medical history findings and oral cavity examination. Russian Medical Association (RMA) index was used to diagnose gingivitis; Green-Vermillion index was used to evaluate oral hygiene status. Results -Changes in the general health of adolescents suffering from periodontal diseases are reported to give evidence of host defense mechanism decrease. Therefore, the treatment is stated to obligatory affect both -the inflammatory process itself and the entire immunity increase. In that case, immunocorrectors application, namely "Imudon", is regarded to be the most reasonable measure. "Imudon" is known to affect the recovery of the regular residential flora in the human oral cavity and has the anti-inflammatory effect as well. "Imudon" application leads to reduction of mucus periodontal pathogens amount. Dissolving in the oral cavity these tablets activate host defense mechanism. Due to excipients active components of this medication remain in the oral cavity for a long-term period. Conclusion -There was established the correspondence between blood plasma immunological indication changes in children with chronic catarrhal gingivitis receiving "Imudon" therapy before and after treatment.