In medicine, the current method of treatment of various pathologies — ozone therapy is gaining popularity. On the basis of modern literary data, the advantage of the use of ozone therapy in the complex treatment of certain diseases has been shown, as well as the main contraindications have been identified. The main task of ozone therapy is to improve tissue circulation, as well as to promote better supply of oxygen to cells, which has a positive effect and accelerates tissue regeneration. It has been found that ozone therapy is widespread in more than ten sanatoriums of the Republic of Crimea. Data on the use of ozone therapy in some sanatoriums of Crimea, such as “Sanatorium Kirov”, “Poltava Crimea”, “Tavria”, in sanatorium named after N. I. Pyrogov, “Slavutich”, “Mishor”, “Ai-Petri” and hotel complex “Yalta-Inturist” are presented. The review describes possible methods of ozone therapy, as well as some peculiarities of ozone use in sanatorium treatment.