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Activity of the major neurotransmitter systems in the brainstem and cerebellum was studied in rats with morphine withdrawal syndrome. The most significant changes were found in the brainstem of animals by the 36th hour and 7 days after morphine withdrawal. Dysfunction was revealed in the dopaminergic, noradrenergic, and serotoninergic neurotransmitter systems. Changes in cerebellar neurotransmission were most pronounced by the end of the first week of morphine withdrawal syndrome and manifested in the prevalence of inhibitory processes.

Activities of GABA-catabolising enzymes and the contents of some amino acids have been studied in the liver of the rats with different types of alcohol cessation after its systemic administration. Intermittent alcohol intoxication was accompanied by activation of liver GABA catabolism in case of the lowest alcohol load. However ethanol in higher doses and prolongation of intermittent alcohol administration decreased GABA catabolism. It is suggested that the observed changes may reflect non-specific adaptation of hepatocytes to the excessive alcohol consumption and its further cessation.

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