The specific features of photon diffusion of low-coherence pulsed irradiation in phantoms of soft biological tissues (blood-saturated tissues of the brain, breast, etc.) are described. The results of photon migration simulation using the Diffusion Approximation to the Radiation Transfer Equation (RTE) are compared with ones of the Monte Carlo simulations. It has been confirmed that the Photon Density Normalized Maximum (PDNM) moves towards the center of the investigated object in case of relatively uniform and strongly scattering media. In the presence of inhomogeneities, type of the PDNM motion changes drastically. Presence of an absorbing inhomogeneity in the medium directs trajectory of the PDNM motion of towards the point symmetric to the inhomogeneity relative to the geometric center of the investigated object. In case of scattering the PDNM moves toward the direction of the center of the scattering inhomogeneity.