Phytochemical analysis of the ethanolic extract of Maclura pomifera fruits yielded four new compounds (I–IV) along with eleven known compounds (V–XV). The crude extract exhibited significant activity towards cannabinoid receptors (CB1: 103.4% displacement; CB2: 68.8% displacement) and possibly allosteric interaction with δ and μ opioid receptors (−49.7 and −53.8% displacement, resp.). Compound I was found to be possibly allosteric for κ and μ opioid receptors (−88.4 and −27.2% displacement, resp.) and showed moderate activity (60.5% displacement) towards CB1 receptor. Compound II exhibited moderate activity towards cannabinoid receptors CB1 and CB2 (47.9 and 42.3% displacement, resp.). The known compounds (V–VIII) exhibited prominent activity towards cannabinoid receptors: pomiferin (V) (IC50 of 2.110 and 1.318 μM for CB1 and CB2, resp.), auriculasin (VI) (IC50 of 8.923 μM for CB1), warangalone (VII) (IC50 of 1.670 and 4.438 μM for CB1 and CB2, resp.), and osajin (VIII) (IC50 of 3.859 and 7.646 μM for CB1 and CB2, resp.). The isolated compounds were also tested for inhibition of human monoamine oxidase-A and monoamine oxidase-B enzymes activities, where all the tested compounds showed fewer inhibitory effects on MAO-A compared to MAO-B activities: auriculasin (VI) (IC50 of 1.91 and 45.98 μM for MAO-B and MAO-A, resp.).

Phytochemical analysis of the ethanolic extract of Maclura pomifera fruits yielded four new compounds (I-IV) along with eleven known compounds (V-XV). The crude extract exhibited significant activity towards cannabinoid receptors (CB1: 103.4% displacement; CB2: 68.8% displacement) and possibly allosteric interaction with and opioid receptors (−49.7 and −53.8% displacement, resp.). Compound I was found to be possibly allosteric for and opioid receptors (−88.4 and −27.2% displacement, resp.) and showed moderate activity (60.5% displacement) towards CB1 receptor. Compound II exhibited moderate activity towards cannabinoid receptors CB1 and CB2 (47.9 and 42.3% displacement, resp.). The known compounds (V-VIII) exhibited prominent activity towards cannabinoid receptors: pomiferin (V) (IC 50 of 2.110 and 1.318 M for CB1 and CB2, resp.), auriculasin (VI) (IC 50 of 8.923 M for CB1), warangalone (VII) (IC 50 of 1.670 and 4.438 M for CB1 and CB2, resp.), and osajin (VIII) (IC 50 of 3.859 and 7.646 M for CB1 and CB2, resp.). The isolated compounds were also tested for inhibition of human monoamine oxidase-A and monoamine oxidase-B enzymes activities, where all the tested compounds showed fewer inhibitory effects on MAO-A compared to MAO-B activities: auriculasin (VI) (IC 50 of 1.91 and 45.98 M for MAO-B and MAO-A, resp.).

В этой статье представлена общая информация о химических и лечебных свойствах коровяка джунгарского (Verbascum songaricum Schrenk). Написано о перспективности и актуальности изучения коровяка джунгарского (Verbascum songaricum Schrenk) как лекарственного растительного сырья This article provides general information on the chemical and medicinal properties of the Djungarian mullein (Verbascum songaricum Schrenk). It is written about the prospects and relevance of the study of the Djungarian mullein (Verbascum songaricum Schrenk) as a medicinal plant material

В данной статье предусмотрен технология получения жидкого экстракта из растений сумаха пушистого (rhus typhina l.). Для получения жидкого экстракта в качестве экстрагента использовали 70% этиловый спирт. В качестве эффективного и оптимального метода был использован метод перколяции. This article provides a technology for producing a liquid extract from the plants of rhus (rhus typhina l). To obtain a liquid extract, 70% ethyl alcohol was used as an extractant. The percolation method was used as an effective and optimal method.