An effective method to calculate the potential energy of a dinuclear system is suggested. The nuclear part of the nucleus-nucleus potential is taken in the double folding form. The analytical expressions obtained allow one to simplify the calculations of interaction between two nuclei except the nuclei near the drip lines. The relationship between the double folding potential and the proximity potential is found. The influence of a deformation and a relative orientation of nuclei on the interaction potential is investigated. The method is applied to the calculations of the energies of the dinuclear and trinuclear systems.

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