Topical issues of medical waste compliance with Federal Law 89-ФЗ On Production and Consumption Wastes and aspects of conducting medical waste management activities in order to comply with this regulatory legal act are considered. It has been established that when medical waste falls under the federal law FZ-89, additional requirements for conducting waste management activities are not taken into account, the entry of medical waste into the Federal Classification Catalog of Waste (FCCW) as a separate unit and optimization of the certification of medical waste. In our opinion, there are currently gaps in the medical waste management activities in the environmental legislation of the Russian Federation and, as a consequence, in law enforcement practice. An algorithm of scientifically based approaches to solving the main problems of the existing problems that can be applied during the preparation and development of the Information and Technical Guide on the best available technologies (BAT) for medical waste management is proposed.

The report presents the results of a review and discussion on providing qualified personnel for radiation medicine facilities and suggests approaches to personnel training. Qualified personnel availability comes first among the principles of quality control of radiopharmaceuticals (RP), supply of modern equipment, access to up-to-date regulatory documents, validated control methods and the organization of internal audit system. Also, radiation medicine facilities workers are inevitably exposed to harmful hygienic factors of the working environment throughout the entire life cycle of RP: the development, testing, production and civil circulation. Nuclear and radiation medicine facilities place the environment at risk of negative impact. Highly qualified specialists (responsible parties) should have knowledge, skills and abilities provided by special basic education are required to assess sanitary, hygienic and environmental risks and to comply with the quality management system requirements for the stable operation of radiation medicine facilities.

Due to the increasing influence of chemical factors on the human body, the experiment has been conducted using organophosphorus compounds (OPC) to stimulate poisoning cases in the production facilities. Given that the development of respiratory failure is a specific organophosphate poisoning symptom, a comparative analysis of external respiratory function (ERF) in rats with intratracheal and intraperitoneal administration of diisopropyl fluorophosphates (DFP) has been carried out. During the research, the average lethal doses of the toxic chemicals have been established, the conditions of DFP intoxication have been modeled. Thus, LD16 was 0.284 mg/kg by intratracheal administration, 1.6 mg/kg by intraperitoneal administration. Experimental data have shown that the intratracheal intake of OPC causes the development of respiratory failure in the first minutes after poisoning. The return of the ERF indicators to the background values was noted a day after poisoning. With the intraperitoneal administration of the toxic chemical, the rate of development of ERF disorders was lower, toxic effects persisted for two days. The data obtained can be used to make appropriate recommendations for the prevention of accidents and non-emergency cases in a production facility.