Nephrotic syndrome is one of the most common glomerulopathies in children, accompanied by a high risk of thrombosis due to hypoalbuminemia, hypovolemia, hyperlipidemia, hyperfibrinogenemia, and antithrombin III deficiency. The article describes a clinical case of iliofemoral thrombosis in a 16-year-old boy with recurrent nephrotic syndrome and primary thrombophilia (heterozygote F5 — Leiden mutation) was diagnosed. The presented clinical observation indicates the multifactorial origin of thrombotic complications in nephrotic syndrome, caused by a combination of an imbalance between the proand anticoagulant components of the blood coagulation system and individual risk factors (severity of proteinuria, hypoalbuminemia, comorbidity, hereditary thrombophilia), and therefore further study is needed to determine the tactics of prevention and treatment.

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The guide will allow pediatricians to get information about the meaning of eponymous terms that they face in practice, educational and scientific activities, it contains 1212 eponymous symptoms, samples and reflexes, 752 symptom complexes, syndromes and diseases relevant to pediatric practice. The book consists of two parts, the first part includes the semiotics of pediatric diseases and presents their symptoms and signs. In the second part of the guide are syndromes and nosological units, which are systematized in alphabetical order. Their interpretation, historical information, data on epidemiology, etiology, pathogenesis and clinical picture of nosological units are given. From the standpoint of evidence-based medicine provides information on the diagnosis, treatment and prevention of these conditions, which may occur in the practice of a pediatrician. The guide is addressed to pediatricians, it is useful to researchers, teachers of higher medical school.

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