Aim: to evaluate the efficacy of Picoprep for colonoscopy preparation in women with pelvic pathology.Patients and methods: during the period from January 2018 to December 2018 in the Federal State Budgetary Institution «National Medical Research Center of Obstetrics, Gynecology and Perinatology named after V.I.Kulakov’’ of the Ministry of Health of the Russian Federation, 873 diagnostic video-colonoscopies were performed on women of reproductive age (from 23 to 41 years of age) in the surgical department of the Department of Operational Gynecology and General Surgery. Macrogol and Picoprep were used in preparation for the study. 512 (58.7%) of the total number of performed colonoscopies were performed after colon preparation with Picoprep.Results: quality of colon preparation with Picoprep: excellent – 168 (32.7%), good – 275 (53.7%), satisfactory – 66 (13%), unsatisfactory – 3 (0.6%).Conclusion: The effectiveness of Picoprep does not differ from the quality of preparation with the use of alternative preparations of Macrogol, but significantly exceeds them in tolerability by patients.