Self-education is the essential factor of personal, collective and social stability, the means of education during the whole life. General educational skills are the essential for self-education. The article considers the 12 years multidisciplinary studies of results of general educational skills formation. It describes the experience of complex application of psychological, physiological, medical and sociological methods. Multidisciplinary approach helps to show the connection between the inclusion of general educational skills in requirements of the federal state educational standard and solution of educational problem for sustainable development: rise of education availability for everyone, support of informationpsychological safety in global world, formation of skills to think connecting different life sides. Increase in level of all-educational results leads to growth of educational motivation, physiological and psychological resistance to information stress. Feedback connection of the general educational skills level with the frequency of psychosomatic complaints expressed vago-and a sympathicotonia, as well as with the "stuck" profiles of cognitive regulation is revealed. Low level of regulatory universal educational skills increases the informational and psychological risks of training. It was revealed that the effectiveness of the formation of general educational skills is enhanced by using "paired" cognitive strategies in teaching ("cognitive swings"), for example, analysis-synthesis and vice versa.