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Current guidelines of acne treatment are not effective in different women. Dissatisfaction with the esthetic results of treatment creates the need to optimize the treatment of late acne in active reproductive aged women.Objective of the study: to evaluate the effectiveness of developed comprehensive method for the treatment of late acne in active reproductive aged women.Materials and methods. 32 patients with acne tarda aged 25–40 years were examined and treated, including women with acne of I degree of severity – 18.8%, II degree – 30.6%, III degree – 46.8%. Biophysical parameters of skin (fat, moisture, elasticity and erythema degree) were determined before treatment, after 3 and 6 months and expressed in arbitrary units. The control group consisted of 8 conditionally healthy women of the corresponding age without acne. Treatment efficacy was evaluated in 3 comparison groups: group 1 – 10 patients who received conventional therapy; group 2 – 12 patients in whom traditional therapy was combined with combined oral contraceptive (COC) Belara, group 3 – 10 patients in whom traditional therapy was combined with COC Belara and Richter CycloBalance.Results. A comparative analysis of the inflammatory dynamics (papules, pustules, nodes, cysts) and non-inflammatory rash elements (open and closed comedones), skin biophysical parameters (fat, porosity, hydration, erythema, elasticity) before treatment, after 3 and 6 months of therapy showed the advantage of combined use COC Belara and Richter CycloBalance in the complex treatment of late acne in active reproductive aged women.Conclusion. Complex therapy of late acne in active reproductive aged women with COC Belar and Richter CycloBalance increases the effectiveness of therapy and aesthetic skin status.

Modern literature information on the etiopathogenetic prevalence of lichen sclerosus has been presented by the authors; clinical manifestations and classification of the disease have been outlined; diagnosis and treatment issues have been discussed in the article. 3 clinical cases of genital lesions in the form of lichen sclerosus in patients with limited scleroderma have been described. In our opinion, lichen sclerosus is one of the forms of limited scleroderma. Purpose. To investigate the conditions for the diagnosis and treatment of genital lesions in the form of lichen sclerosus in patients with limited scleroderma. Methods. The first line of therapy for lichen sclerosus is the use of super-powerful topical glucocorticoids. Clobetasol propionate 0.05% is to be used for 3 months (1 month daily, then every other day for a month, then 2 times a week for a month). After 3 months of treatment, if a positive effect is declared, maintenance therapy is recommended once a week. Topical calcineurin inhibitors are recommended as a second-line therapy. Effective and safe excipients are emollients that moisturize the skin and mucous membranes, prevent transdermal fluid loss, and reduce subclinical inflammation. The possibility of using triamcinolone (1-2 mg) onto pathologically altered tissue in women with lichen sclerosus where there are hyperkeratotic sites resistant to GCS can be considered after exclusion of intraepithelial neoplasia or malignant transformation. The effectiveness of physiotherapeutic methods, such as low-intensity helium-neon laser radiation in the red or infrared range, treatment with sunlight and radiation generated by medical equipment, photodynamic therapy has been described. Results. One of the important measures is the elimination of irritating factors, as well as careful care of the vulva and the treatment of secondary infection. It consists in adherence to a diet (exclusion of spicy, salty, sweet foods, caffeine-containing products, alcohol) and intimate hygiene rules (limitation / exclusion of soap-containing products, deodorants, synthetic underwear, pads, tampons). The underwear should not be very tight. In addition, patients should exclude mechanical irritation of the affected area, including shaving. With extreme manifestation of itching, it is recommended to prescribe desensitizing therapy and sedatives. Conclusions. Clinical cases of practical interest in connection with the clinical manifestations of limited scleroderma on the skin and genitals have been considered. Frequent lesions of the genital organs in the form of a typical clinic of lichen sclerosus in women suffering from limited scleroderma, the similarity of their clinic, histological picture and pathogenesis have been noted. All this gives a reason to consider lichen sclerosus as a manifestation of limited scleroderma.

The aim of the study: to study the efficacy of ointment Ilon in complex treatment of patients with limited pustular psoriasis. Materials and methods. Patients with limited pustular psoriasis (n=32) were divided into two groups. To the main group (n=21) were included patients, combined therapy which included application of ointment Ilon. In the comparison group (n=11) patients underwent conventional therapy, the effectiveness of which was evaluated by the analysis of the immediate and remote results of treatment. Results. Clinical1anamnestic analysis showed that the endocrine disruption was revealed in 87.5% of patients, most often in women (88.5 %). Excess body weight was 65.6% of patients (73, 1% were female and 33.3% male). During the analysis of the immediate and remote results of treatment, the best results had those patients, who combined therapy which included the external application of ointment Ilon. Remission at end of treatment was detected in 60% of patients with psoriasis, including 70% of patients of the main group and 50% in the control group. Sustainable clinical result during the year was observed in a total of 81.25% of patients, including 85.7% of patients of the main group and 72.7 % in the control group. Conclusion. The use of ointment Ilon in the complex therapy of limited pustular psoriasis significantly improves its efficiency, increases the duration of remission. Ointment Elon has a good effect during the using and can be used in combination with light therapy and other physiotherapeutic methods of treatment.