Objective. Evaluate the main criteria for ASL-liver perfusion in viral hepatitis.Material and methods. 111 patients with viral hepatitis, including 69 (62.2%) men and 42 (37.8) women, were examined on the basis of “Clinical hospital N 1”, Smolensk. The average age of patients was 48 ± 5.4 years. All subjects (n = 111) underwent abdominal ultrasound with Doppler vascular examination, clinical elastography, and ASL-liver perfusion with magnetic resonance imaging (MRI). The reference method was trepan liver biopsy in 69 (62.1%) people.Results. Patients were observed for 9 months. A proportion of the prognosis of the course of the viral hepatitis was compiled, followed by a coefficient-PHBF/PABF, where PHBF is the coefficient of blood flow in the liver parenchyma, PABF is the blood flow in the hepatic artery or abdominal aorta. According to the results of observation of patients, it was found that 54 (48.6%) received more than 1, and 57 (51.3%) had a prognosis coefficient of less than 1. There was a high correlation between positive clinical and laboratory dynamics and an increase in ASL-perfusion of the liver (r = 0.889), as well as negative clinical and laboratory dynamics and a decrease in ASL-perfusion of the liver (r = 0.887). it was found that in patients with a minimum degree of VH activity, the volume of hepatic blood flow (HBF) according to ASL-perfusion of the liver during MRI was from 140 – 159 ml/100 g/min, with a moderate – 118–139 ml/100 g/min, with high – 40–117 ml/100 g/min.Conclusion. Thus, if the ratio of forecast of more than 1 predict a favorable course (AUC = 0,897 (95% CI 0,884– 0,951)), with a coefficient less than 1 is unfavorable (AUC = 0,895 (95% CI 0,881–0,953)).

Currently, it is necessary to find additional reliable technique (and without prejudice to the health of the patient with diffuse liver disease) to determine the stage of the disease, to quickly evaluate the degree of fi-brosis, including dynamics, as well as to predict the further course of the disease. It is known that changes in patients with diffuse liver disease at the vascular level are systemic in nature. Identification of these changes may help predict disease course, the possibility of the therapy revising. Clinical perspectives, the benefits of using non-invasive laser Doppler imaging as a method of diagnosis of the microvasculature in patients with diffuse liver diseases are discussed in this paper. 40 patients with alcoholic liver cirrhosis, with steatohepatitis mixed etiology, viral hepatitis "B" and "C" of varying degrees of activity, which conducted the study of microcirculation using non-invasive laser Doppler were examined.