During the first year of the new coronavirus (COVID-19) pandemic, more than 60 million people were infected. Of these, almost 20% had the consequences after it, the so-called “Post-COVID syndrome”, which manifests itself in various long-term painful symptoms. The causative agent of the disease, the coronavirus SARS-CoV-2, primarily affects the lung tissues and disrupts gas exchange that leads to acute respiratory distress syndrome, systemic hypoxia, when, first of all, the blood saturation system is destroyed. Severe complications of this infection require the active development of methods to eliminate and prevent the consequences of infection with coronavirus. Therefore, the search for effective rehabilitation method, especially of the respiratory system specifically after suffering from pneumonia caused by COVID-19, is extremely urgent. As a result of numerous studies, the possibility of using the method of normobaric interval hypoxic training was justified. At the same time, the respiratory surface and the number of alveoli in the lungs increase, the mass of the respiratory muscles increases and the neurons of the respiratory center hypertrophy occurs as a result of which the efficiency of the ventilation function increases. Inflammation in the lungs can last for several weeks and then fibrosis occurs in place of the damaged areas. This shows the absolute need for effective methods of rehabilitation, first of all, of the bronchopulmonary system after suffering from pneumonia caused by COVID-19. Interval hypoxic training, as an effective non-specific method of increasing the body’s defenses is indispensable in rehabilitation after viral pneumonia. It is shown that the combined use of interval hypoxic training and the method “Detensor” for the gentle long-term traction of spinal column can reduce or eliminate ventilation and perfusion disorders in chronic obstructive pulmonary disease. This justifies the possibility of using these methods for correction of bronchopulmonary disorders as a non-invasive and non-pharmacological support in the complex of rehabilitation measures for Post-COVID syndrome.

BACKGROUND: Interval hypo-hyperoxic training is a new promising technology in medical rehabilitation, including the rehabilitation of patients with post-COVID syndrome. However, the mechanisms of therapeutic action of interval hypo-hyperoxic training in the recovery period after suffering COVID-19 have not been fully studied. The effectiveness of interval hypo-hyperoxic training largely depends on the method of interval hypo-hyperoxic training. AIM: to develop modes and study the effectiveness of the use of interval hypoxic training in patients with post-COVID syndrome. MATERIALS AND METHODS: The performed open randomized comparative study involved patients with a diagnosis of post-COVID syndrome ― "Condition after COVID-19" according to the ICD (code U09.9). Patients of the main group, against the background of a course of traditional rehabilitation treatment, received interval hypo-hyperoxic therapy from the OXYTERRA device. In the comparison group, patients received only a traditional course of rehabilitation treatment. The study was conducted for 4 months. To assess the effectiveness of interval hypo-hyperoxic training before and after the course of rehabilitation, we studied the dynamics of the parameters of the circulatory system and the function of external respiration. RESULTS: 50 patients (19 women, 31 men, mean age 61.77.7 years) were randomly divided into the main group (n=30) and the comparison group (n=20). All patients completed a full course of rehabilitation. It was established that the course of training with interval hypo-hyperoxic training contributed to an increase in the oxygen capacity of the blood, an increase in the oxygen content in arterial blood, a decrease in heart rate, normalization of the level of systolic and diastolic pressure, restoration of stroke and minute blood volume parameters in patients of the main group. Interval hypo-hyperoxic training caused an improvement in the functional state of the bronchopulmonary system (p 0.049). There was an improvement in the activity of the central ergotropic and humoral-metabolic mechanisms of heart rhythm regulation, correction of the activity of the sympathetic link of regulation and the modulating effect of the parasympathetic division on the heart rhythm, normalization of the vagosympathetic balance coefficient. CONCLUSION: The use of interval hypo-hyperoxic training in the recovery period in patients with post-COVID syndrome according to the developed method caused a stable improvement in the clinical condition, which lasted from 3 to 6 months after the completion of complex rehabilitation.

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