Poststroke depression (PD) is considered as a common medical and social problem. Depression is estimated to occur in 30-35% of the patients during the first year after stroke. Despite the high level of comorbidity, PD is frequently undetectedand and untreated. Psychological impairment from stroke has a negative effect on functional outcome, rehabilitation and quality of live. On the basis of literature review present prevalence, etiology, pathogenesis,diagnosis of PD and summarize current recommendations for therapeutic intervention. A rational approach to the treatment and prevention of PD is proposed.