5-Hydroxy-7-methyl-3H-thiazolo [4,5-b]pyridin-2-one was obtained by the reaction of 4-iminothiazolidin-2-one with acetoacetic ester. Further structural modifications include the introduction of diversity at the C 5 and C 6 positions. The anti-inflammatory action of novel thiazolo[4,5-b]pyridine-2-one derivatives was evaluated in vivo employing the carrageenan-induced rat paw edema method. The antioxidant activity of the synthesized compounds was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.

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The spectrophotometric behavior of a new, first-time synthesized reagent -4-[N'-(4-imino-2-oxo-thiazolidin-5-ylidene)-hydrazino]-benzenesulfonic acid (ITHBA), has been investigated. A simple, rapid, accurate, selective and sensitive method for the spectrophotometric determination of Pd(II) ions using this reagent was developed. The optimal conditions for the formation of the complexes were found. The molar absorptivity at λ = 438 nm is 7.5 × 10 3 L mol -1 cm -1 , and Beer's law is observed for the concentrations ranging from 0.2-2.2 μg mL -1 Pd(II). The effects of extraneous ions were investigated. The method proved to be successful in determination of palladium in the intermetallides and resistor. The accuracy of spectrophotometric palladium assay in real objects with 4-[N'-(4-imino-2-oxo-thiazolidin-5-ylidene)-hydrazino]-benzenesulfonic acid has been confirmed by voltammetric or atomic absorption spectroscopy method.

The interaction of Ru(IV) ions with a novel analytical reagent-5-hydroxyimino-4-imino-1,3-thiazolidin-2-one, by spectrophotometric method was investigated. The complex is formed at pH 5.0 in acetate buffer medium after heating in the boiling water bath (~371 K) for 25 min. The complex has maximum absorption at 350 nm and is stable for 24 h. Beer's law is valid over the concentration range of 0.5-6.1 µg mL-1 for Ru(IV). The molar absorptivity at λ = 350 nm is 6.21 × 10 3 L mol-1 cm-1. The limit of detection of this method is 0.2 µg mL-1. The interfering effect of various cations and anions on the spectrophotometric determination of the Ru(IV) were investigated. The proposed method was successfully applied to the determination of Ru(IV) in alloys.

The antioxidant activity of novel N 3 and C 6 substituted 5,7-dimethyl-3H-thiazolo [4,5-b]pyridine-2one derivatives was evaluated in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The correlation analysis between the antioxidant activity and different subsets molecular descriptors was carried out for 19 compounds. The regression models derived with QSAR-analysis display the significant influence of topological structure, atom and bond type counts, physicochemical properties, and quantum-chemical structure parameters on the free radical scavenging effect of the compounds.