Background — According to the data from the published sources worldwide, about 10% of the world population suffers from osteoarthrosis. While searching for novel methods of osteoarthrosis treatment, we proposed administering intra-articular injections of autologous platelet-rich plasma. The goal of this clinical study was to evaluate the effectiveness of autologous platelet-rich plasma injections in osteoarthrosis patient treatment. Methods — This open-label parallel-group study was a pilot randomized controlled trial. An analysis of the treatment outcomes for 128 patients with knee joint arthrosis was performed. All patients were split among three groups, and subjects in two of those were receiving conventional treatment. Clinical efficacy was calculated from pain intensity, determined using Visual Analog Scale, Lequesne index and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Inflammatory response intensity was assessed by superoxide dismutase content and erythrocyte catalase activity. Results — It was demonstrated that administering platelet-rich plasma allowed achieving tangible clinical and laboratory results without any side effects and with very few contraindications. The latter included, for instance, blocking inflammatory process in the joints, thereby inhibiting the oxidative stress, which is the most pathogenetically substantiated treatment of osteoarthrosis. Conclusion — Thus, we have discovered that platelet-rich plasma injections had apparent anti-inflammatory and pain-relieving effects, along with inhibiting action of destructive processes in the cartilaginous tissue, hence improving life quality of the patients with osteoarthrosis.
Проведен анализ эффективности применения элементов fast-track-хирургии в лечении больных с острой хирур-гической патологией, осложненной распространенным перитонитом. С этой целью в ходе анализа больные были разделены на две группы: к первой (контрольной) отнесены 35 пациентов (ретроспективный анализ историй бо-лезней), лечение которых проводилось по стандартной схеме -оперативное вмешательство, адекватная антибак-териальная терапия, общепринятая инфузионная терапия, анальгетики. Вторая группа (основная) -35 больных, лечение которых дополнялось элементами fast-track-хирургии. Клинические и лабораторные данные свидетель-ствуют об ускоренном восстановлении нормальной перистальтики кишечника, белковых показателей, меньшем показателем осложнений в основной группе относительно контрольной. На основании полученных данных можно сделать вывод об эффективности применения элементов fast-track-хирургии в лечении больных с острой хирурги-ческой патологией, осложненной распространенным перитонитом.Ключевые слова: fast-track-хирургия, распространенный перитонит. Russia, Republic of Crimea, 295006, Simferopol, Lenin Boulevard, 5/7; e-mail: pancreas1978@mail.ru The analysis of the effectiveness of the use of certain elements of fast-track-surgery in the treatment of patients with acute surgical pathology, complicated widespread peritonitis. To this end, during the analysis, patients were divided into two groups: the first (control) assigned 35 patients (retrospective analysis of case histories), whose treatment was carried out in the normal way -surgery, adequate antibiotic therapy, conventional infusion therapy, analgesics. The second group (basic) -35 patients whose treatment was supplemented by some elements of the fast-track-surgery. Clinical and laboratory evidence of accelerated recovery of normal intestinal motility, protein index lesser than the complications in the first group relative to the second. conclusion about the effectiveness of the elements can be made on the basis of the data fast-track-surgery in the treatment of patients with acute surgical pathology, complicated widespread peritonitis. V. YU. MYKAHYLICHENKO, YU. I. BASNAEV, N. E. KARAKURSAKOV ANALISIS OF THE USE OF THE SAMESING ELEMENTS FAST-TRACK-TO SURGERY TREATMENT TO PATIENT WHICH WIDESPREAD PERITONITIS Medical Academy named after S.I. Georgievskiy, The Federal State Autonomous Educational Establishment of Higher Education «Crimean Federal University named after V.I. Vernadsky» Ministry of Education and Science of the Russian Federation,
Aim. This research was conducted to study the possibility and effectiveness of the "Fast-track" fast recovery program application when performing simultaneous operations against the background of widespread peritonitis.Materials and methods. In the course of the study were examined 66 patients, the ratio of woman/man was 45:21. The main group – 32 (48,5%) patients with the major disease of constricted postoperative hernia complicated by the widespread peritonitis and chronic calculous cholecystitis (a prospective analysis of surgical treatment). The comparison group – 34 (51,5%) patients with the identical pathology – the retrospective analysis of surgical treatment. The treatment of patients of the main group was supplemented with the application of the elements of the «Fast-track» program. Whereas, the treatment of patients of the comparison group was performed exclusively according to the standard scheme of the patient management with widespread peritonitis.Results. Clinical, laboratory and instrumental data indicate the positive effect of the "Fast-track" program on the process of rehabilitation of patients in the postoperative period. There was a significant acceleration in the recovery of motorevacuation function of the intestine in patients of the main group in relation to the comparison group and a smaller number of complications in the main group in relation to the comparison group against the background of the application of this technique. As a result, the average duration of hospitalization of patients from the comparison group was 10- 5 days (average 12±2,4 days). While the average duration of hospitalization of patients from the comparison group was 17-20 days (on average 18±1,2 days).Conclusion. The use of the "Fast-track" program in simultaneous operations does not increase the effectiveness of surgical treatment, thereby accelerating the process of rehabilitation of patients in the postoperative period.
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