Abzhanov Arkhat, prof. (Boston, USA), Abelev S.K., prof. (Moscow, Russia), Aitkhozhina N.А., prof., academician (Kazakhstan) Akshulakov S.K., prof., academician (Kazakhstan) Alchinbayev М.K., prof., academician (Kazakhstan) Batpenov N.D., prof., corr. member (Kazakhstan) Berezin V.Ye., prof., corr. member. (Kazakhstan) Bersimbayev R.I., prof., academician (Kazakhstan) Berkinbaev S.F., prof. (Kazakhstan) Bisenbayev А.K., prof., academician (Kazakhstan) Bishimbayeva N.K., prof., academician (Kazakhstan) Botabekova Т.K., prof., corr. member. (Kazakhstan) Bosch Ernesto, prof. (Spain) Davletov Kairat, PhD, associate professor, executive Secretary Dzhansugurova L.B., Cand. biol., prof. (Kazakhstan) Ellenbogen Adrian, prof. (Tel-Aviv, Israel), Zhambakin K.Zh., prof., academician (Kazakhstan), deputy editor-in-chief Ishchenko Alexander, prof. (Villejuif, France) Isayeva R.B., prof. (Kazakhstan) Kaydarova D.R., prof., academician (Kazakhstan) Kokhmetova A., prof., corr. member (Kazakhstan) Kuzdenbayeva R.S., prof., academician (Kazakhstan) Lokshin V.N., prof., corr. member (Kazakhstan) Los D.А., prof. (Moscow, Russia) Lunenfeld Bruno, prof. (Israel) Makashev E.K., prof., corr. member (Kazakhstan) Mitalipov Sh.M. (America) Muminov Т.А., prof., academician (Kazakhstan) Ogar N.P., prof., corr. member (Kazakhstan) Omarov R.T., cand. biol., prof. (Kazakhstan) Prodeus A.P., prof. (Russia) Purton Saul, prof. (London, UK) Rakhypbekov Т.K., prof., corr. member. (Kazakhstan) Saparbayev Мurat, prof. (Paris, France) Sarbassov Dos, prof. (Houston, USA) Turysbekov E.K., cand. biol., assoc. prof. (Kazakhstan) Sharmanov A.T., prof. (USA) News of the National Academy of Sciences of the Republic of Kazakhstan. Series of biology and medicine.

The aim of this work is to develop an effective and economical technology for extracting the sum of extractive substances from raw materials of Peganum harmala L. roots by percolation method. The plant material is the roots of Peganum harmala L., collected in October 2017 in the vicinity of the village of Akshi (Almaty region, Kazakhstan). Maceration was carried out on the pilot unit ERSND-1 (Karaganda, Kazakhstan). Percolation was carried out on extractor P-250 (Tomsk, Russia). Quantitative analysis of the content of harmine in the amount of extractive substances was determined by HPLC with a UV-detector method. Various factors affecting the efficiency of extracting the sum of alkaloids from the roots of Peganum harmala L. by maceration and percolation method are reviewed and compared in this work. It has been established that percolation is the preferred extraction method for the sum of extractive substances, which makes it possible to reduce the extraction process by 5 times compared to maceration. The optimal processing parameters and grinding of raw materials of Peganum harmala L. roots, as well as the technological parameters of extraction, providing a quantitative yield of the sum of alkaloids were established. The studies show the promise of using the percolation method and the need for further work on the implementation of the developed technology for the extraction of Peganum harmala L. alkaloids in the production of the substance of the neurotropic drug "Harmine hydrochloride".