The paper presents the results of study of the antibacterial effect of silver nanoparticles when ingested, on the experimental model of peritonitis and meningoencephalitis in vivo. In conditions of the increasing resistance of bacteria to antibacterial drags, the search of alternative means which will allow to effectively deal with clinically significant microorganisms, is relevant. Such tools are the nanoparticles of metals, particularly the silver nanoparticles. According to results of conducted research, they show quite a high antibacterial and antiviolence activity. The study prove that at intra-cerebral introduction of pathogenic strains of microorganisms (experimental meningoencephalitis), after per oral use of nanosilver - effect didn´t observed; in the group of animals with intra-peritoneal injection (experimental peritonitis) - the signs of inflammation of the peritoneum by microscopic examination didn´t revealed.

This article presents the results of the study the virulence properties and antibiotic resistance of fungi of the genus Candida isolated from children with acute intestinal infection. Currently, there is an increase in the frequency of fungal infections, and the problem of resistance to antimycotic drugs is more important. The authors investigated 100 isolates of fungi of the genus Candida and they studied their virulent properties and conducted an analysis of resistance to antimycotic drugs. The correlation of the strains had the following values: leading species is C. albicans – 78.6%, then followed C. kruzei, C. glabrata, C. tropicalis (10,6, 7,1 and 3,6% respectively). In most cases the species of fungi Candidaspp. were determined in the intestine in the composition of associations with other members of pathogenic and conditionally pathogenic microflora. The study of the virulence properties of mushrooms allowed to obtain the following data: the ability to filamentation was detected in 100% of tested strains C. albicans, C. krusei – 36% of strains, and the strains of C. glabrata and C. tropicalis has not shown the ability to filamentation. Analysis of antibioticogram of fungi demonstrates the following results: 100% of strains of C. krusei are resistant to fluconazole (this type of natural resistant to the drug), to voriconazole 14% of the strains, and to flucytosine, to amphotericin B 11% and 34%, respectively. Intermediate sensitivity to amphotericin B was observed in 11% of the isolates. The authors revealed the presence of strains of C. krusei associated with resistance (40%) and strains with cross-resistance to 11%. The increase in the minimum overwhelming concentration of antimycotics in strains of C. kruseiс and the associated cross-resistance is observed. 100% of strains of C. tropicalis, and C. glabrata are sensitive to all four drugs.