This article examines the main factors of the emergence of Indo-Pacific Strategy, the balance of powers between China and the United States in the Indo-Pacific Region, and their investment policy into contiguous countries of the region. Special attention is paid to contradictions between China and the United States in the region, as well as the impact of D. Trump’s Indo-Pacific Strategy upon U. S. relations with China. The article explores the main integration structures of Indo-Pacific Region, goals and tasks set before them. The novelty of this research is defined by fact that in incipient competition between the two countries for the leading positions in Indo-Pacific Region is traced in the advanced by China concept “One Belt, One Road” and U. S. strategy of “Free and Open Indo-Pacific”. The author comes to the conclusion that currently there is no unified integrated interregional authority that is capable of solving the entire range of problems faced by the countries of Indo-Pacific Region. However, the United States gradually lose its leading position in the region, yielding to PRC. China’s domestic reforms, aimed at improvement of interregional financial and economic ties, contribute to creation of a positive image of the country and strengthening of PRC’s position in the Indo-Pacific Region.