Aim. To evaluate the interrelationship between diurnal changes in thyrotropic hormone (TTH), free triiodothyronine (FT3), and clinical features of IHD in combination with AH and atrial fibrillation (AF). Materials and methods. Levels of TTH, FT3, and plasma cortisol were measured in 133 patients with IHD and AH with or without paroxysmal AF. The studied indexes included duration of IHD, AH, and AF; presence or absence of AF and AH; incidence rate of AF episodes per week; severity of exertional angina; systolic and diastolic BP; and EchoCG data. Results. Morning and evening TTH levels were significantly different and reached high values in the morning and low values in the evening in most patients (n=91; 68.4%). A part of patients (n=42; 31.6%) showed an opposite tendency with high TTH values in the evening, i.e., inversion of the TTH fluctuations. Such patients more often had a history of myocardial infarction, a high class of exertional angina, and recurrence of paroxysmal AF. Patients with the TTH inversion had a shorter AH duration but somewhat higher BP. Conclusion. A part of IHD patients had inversed TTH circadian changes associated with more severe clinical manifestations of cardiovascular pathology.

Abstract:There was studied the relationship between polymorphic variants of APOC3 (rs2854117), PON1 (rs854560, rs662), AGT (rs4762, rs699) and AGTR1 (rs5186) genes with the results of cognitive tests in patients with chronic heart failure (СHF) of ischemic genesis and healthy persons. The general group included 50 patients with CHF of II-IV functional classes, the control group -50 healthy volunteers. Cognitive functions were estimated by 5 th and 7 th subtests of Wexler and Burdon's test. There was revealed statistically significant correlation between the polymorphism of APOC3, PON1, AGT, AGTR1 genes and the results of cognitive tests in patients with CHF and healthy persons. These data suggest that the polymorphism of the studied genes may be important in the genetic susceptibility to the formation and progression of cognitive disorders. Keywords: polymorphism of genes, chronic heart failure, cognitive disordersCite as Martynovich TV, Akimova NS, Fedotov EA, Schwartz YG. Polymorphism of genes associated with increased cardiovascular risk and cognitive function in patients with chronic heart failure and in healthy persons: the pilot study.

Тихонова Татьяна Андреевна, кафедра терапии, гастроэнтерологии и пульмонологии, аспирант Козлова Ирина Вадимовна, заведующая кафедрой терапии, гастроэнтерологии и пульмонологии, профессор, д. м. н. Федотов Э. А., заведующий лабораторией, к. м. н.

No abstract

2Научный центр психического здоровья РАМН, Москва, Россия (115522, Москва, Каширское шоссе, 34) 3 Центр ДНК исследований, Саратов, Россия (410005, Саратов, ул. Рахова, 280) Было проведено исследование влияния генетического полиморфизма Val66Met гена мозгового нейротрофического фактора (BDNF) на сывороточный уровень BDNF у больных параноидной шизофренией на примере популяции Саратовской области (Россия). В исследовании принимали участие больные параноидной шизофренией (n = 94) и группа здоровых испытуемых (n = 41). Исследовали полиморфизм Val66Met (аллели Val и Met) для гена мозгового нейротрофического фактора BDNF (rs6265 G>A). Концентрацию BDNF в сыворотке крови определяли методом иммуноферментного анализа. Средние показатели уровня мозгового нейротрофического фактора у больных параноидной шизофренией статистически значимо не отличались от аналогичных показателей здоровых лиц. В ходе проведённого исследования была впервые обнаружена ассоциация полиморфизма Val66Met гена BDNF с уровнем белка BDNF в сыворотке крови больных параноидной шизофренией. Аллель Met для полиморфизма Val66Met гена BDNF связана с увеличением периферического уровня мозгового нейротрофического фактора. Ключевые слова: шизофрения, ген BDNF, мозговой нейротрофический фактор. DNA Research Centre, Saratov, Russia (410005, Saratov, Rakhovast., 280) We investigated the influence of Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF gene) on the serum BDNF levels in patients with paranoid schizophrenia as an example of the population of the Saratov region (Russia). The study involved patients with paranoid schizophrenia (n = 94) and a group of healthy subjects (n = 41). We investigated Val66Met polymorphism (Val allele and Met) for BDNF gene (rs6265 G> A). The BDNF concentration in the serum was measured by ELISA. Average indicators of BDNF serum concentration in patients with paranoid schizophrenia were not significantly different from those in healthy persons. In the course of the study was first discovered association Val66Met polymorphism BDNF gene with the level of BDNF protein in the serum of patients with paranoid schizophrenia. Met allele for Val66Met polymorphism BDNF gene is associated with increased peripheral serum levels of brain-derived neurotrophic factor. RESEARCH OF INFLUENCE OF VAL66MET POLYMORPHISM OF THE BDNF GENE ON THE BRAIN-DERIVED NEUROTROPHIC FACTOR SERUM LEVEL IN PATIENTS