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The paper considers comparing the anti-inflammatory action of the food concentrate “Enoant” and a classical antioxidant – resveratrol in the doses of 20 mg/kg in the model of an acute exudative inflammatory of animals. It was proved that resveratrol had the most anti-inflammatory action; this was manifested by a considerable decrease of the increase rate of the animal paw’s size in the formalin test after 7 and 14 days of taking the antioxidant. The food concentrate “Enoant” demonstrated anti-inflammatory properties after 7 days of taking the antioxidant; this was manifested by the increase of the animal paw’s size in the formalin test, however 14 days later a moderate anti-inflammatory reaction was registered, this was manifested by the decrease of the increase rate of the animal paw’s size in the formalin test..

The tissue microhemodynamics plays a significant role in a tissue homeostasis. Any pathological processes were changes in functioning of microhemodynamics. This is causes is significant interesting to safe methods for its correction. One of such methods is exposure to low-intensity electromagnetic radiation of the millimeter (MM) range, which has pronounced of biological activity. The aim of the work was to identify changes in the processes of microcirculation in human skin when exposed to a low-intensity EMR MM range (wavelength - 7.1 mm; power flux density - 0.1 mW/cm2). The study was conducted on 40 volunteer girls aged 18-20 years. The exposure of low-intensity MM radiation was carried out daily for 10 days with an exposure of 30 minutes on the area of biologically active area GI-4. Microcirculation indices were recorded by laser Doppler flowmetry both in the area of influence of MM radiation (contact point of registration) and in the symmetrical effect of the area (distant point) to detect local and systemic changes in tissue blood flow under the action of this physical factor. The results of the study revealed for the first time that when exposed to low-intensity MM radiation, local changes in tissue blood flow in the contact point area were observed, manifested in changes in myogenic and endothelial oscillatory activity, starting from the first sessions of exposure, which indicates a decrease in peripheral resistance of precapillary sphincters and an increase in secretory activity of microvascular endothelium; changes in neurogenic oscillations-starting from the third session, which is accompanied by a decrease in arteriolar resistance; changes in pulse fluctuations - during the last tenth session of exposure, which is an indication of an increase in arteriolar blood filling. These changes were maintained during the entire period of exposure to this physical factor. Systemic changes in microcirculation parameters at a distant symmetrical point during the course action of MM radiation were characterized by changes in the neurogenic oscillator component, starting from the third session of exposure, and changes in the amplitude of endothelial and pulse oscillations - during the tenth session.

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The effect of two supplements containing resveratrol (“Resveratrol” and “Enoant”) on the psycho-emotional state of animals with an initial index of anxiety and depression above 0.5 was studied. For this, the “Elevated plus maze” (EPM) and “Forced swim test” (FST) were used. “Resveratrol” significantly reduces the index of depressivity (ID) in males on the 7th and 14th days of application, in females – only on the 14th day. No significant influence on the anxiety index (AI) was found in both sexes. “Enoant” significantly reduces the ID in males on the 7th day, but not on the 14th day, while no significant differences were observed in females. However, unlike “Resveratrol”, “Enoant” significantly reduces the AI on the 14th day in rats of both sexes.