Objectives to evaluate laboratory and instrumental indicators, associated with decreased left ventricle ejection fraction in patients with heart failure of ischemic etiology. Material and methods. The observational study included 71 patient with coronary heart disease and chronic heart failure (CHF). All patients underwent the testing on the following parameters: uric acid concentration, C-reactive protein (hs-CRP), NT-proBNP, ST2 and cystatin C tests, glomerular filtration rate. Instrumental examination included transthoracic echocardiography and 6-minute walk test. Results. The study revealed several indicators, associated with decreased left ventricle ejection fraction less than 50% in patients with CHF: NT-proBNP level 822.2 pg/ml, ST2 38.61 ng/l, uric acid 419.9 mmol/l, hs-CRP 2.54 mg/l, end diastolic volume index 73.68 ml/m2, left ventricular mass index 127 g/m2, left ventricular contractility index 1.75, pulmonary artery pressure 29 mm Hg. and vena cava inferior diameter 20 mm.