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Background The prevalence of chronic heart failure (CHF) and geriatric syndromes increases with age, however the associations between these conditions have not yet been studied. Purpose To evaluate the associations between CHF and geriatric syndromes in elderly patients. Methods Four hundred and seventy-two in-patients (18% male) aged 75–100 (mean 81±4) years were included in the nursing study. Patients were examined by nurses with a specially designed nursing assessment algorithm that included Mini-Cog test, Morse Fall scale, Norton scale, Barthel Activities of daily living Index, Short Physical Performance Battery (SPPB) tests, Mini Nutritional Assessment (MNA) scale, Geriatric Depression Scale (GDS-15), and a number of other questionnaires. Results CHF was observed in 180 patients (38%). Functional class (FC) of II (NYHA) was diagnosed in 133 (74%) of them, FC of III – in 47 (26%). Patients with and without CHF did not differ by age and gender. CHF patients had lower points on Norton scale (17,6±2,0 vs 18,2±1,8; p<0,001), Barthel Index (92,0±13,9 vs 95,0±9,1; p=0,009), SPPB (5,3±3,2 vs 6,0±3,3; p=0,018), and higher points on Morse Fall scale (44,3±19,9 vs 39,3±21,1; p=0,007) and GDS-15 (4,7±3,2 vs 4,2±3,3; p=0,041) compared to non-CHF patients. CHF patients had higher frequency of frailty (75% vs 65%; p=0,029), depression (47% vs 38%; p=0,041), and cognitive impairment (54% vs 41%; p=0,008). Univariate regression analysis showed that CHF presence increased the frailty risk by 1,6 times (OR 1,59; 95% CI 1,05–2,40; p=0,029), the depression risk – by 1,5 times (OR 1,48; 95% CI 1,02–2,16; p=0,041), and the cognitive impairment risk – by 1,7 times (OR 1,65; 95% CI 1,14–2,40; p=0,009). Among CHF patients, severity of CHF clinical manifestations correlated with severity of geriatric syndromes. CHF patients with FC of II had higher points of Norton scale (17,8±1,9 vs 16,9±2,1; p=0,005), Barthel Index (93,4±12,9 vs 88,3±15,8; p=0,005), SPPB (4,4±3,3 vs 3,9±3,0; p=0,001), walk speed (0,58±0,26 vs 0,45±0,22 m/s; p=0,002), and lower points of GDS-15 (4,4±3,3 vs 5,5±2,9; p=0,008) compared to CHF patients with FC of III. The frequency of depression was higher in CHF patients with FC of III (64% vs 41%; p=0,008). Univariate regression analysis showed that in CHF patients with FC of III the depression risk was higher by 2,5 times (OR 2,50; 95% CI 1,26–4,98; p=0,009) compared to CHF patients with FC of II. Conclusion Elderly CHF patients had higher risk of geriatric syndromes such as frailty, depression, and cognitive impairment. Among CHF patients, severity of CHF clinical manifestations correlated with severity of geriatric syndromes. Funding Acknowledgement Type of funding source: None

В обзоре рассмотрена проблема сочетанной патологии щитовидной железы и сердечно-сосудистой системы, которая в настоящее время наблюдается достаточно часто. Представлены особенности течения кардиоваскулярных заболеваний при субклинической дисфункции щитовидной железы. Освещена теория об изменении суточных ритмов секреции тиреоидных гормонов как начальных проявлений нарушения функции щитовидной железы. В настоящее время отмечается возрастание интереса к изучению биоритмов организма и их изменений при формировании той или иной патологии. В связи с этим особое внимание уделяется роли клеточных, гуморальных механизмов регуляции биологических ритмов и их влияния на развитие и течение сердечно-сосудистых заболеваний. Приведены экспериментальные данные, результаты пилотных и проспективных исследований, посвященных изменениям биоритмов у пациентов с ишемической болезнью сердца, фибрилляцией предсердий, хронической сердечной недостаточностью. Описываются особенности ритмической деятельности щитовидной железы при сердечно-сосудистой патологии. В заключении указывается, что более глубокое изучение индивидуальных биоритмических особенностей организма помогло бы получить дополнительное представление о механизмах развития и прогрессирования заболеваний и создать перспективы для внедрения новых эффективных методов лечения. We considered the problem of the combined pathology of the thyroid gland and the cardiovascular system, which is currently quite often observed. The main features of cardiovascular diseases in subclinical thyroid dysfunction are presented. The authors highlighted the theory of changes in the daily rhythms of secretion of thyroid hormones as the initial manifestations of thyroid dysfunction. Currently, there is the increase of interest in the study of biological rhythms and their changes in the pathology. Special attention was paid to the role of cellular and humoral mechanisms of regulation of biorhythms and their influence on the development and progression of cardiovascular diseases. There are presented the results of experimental evidences, pilot and prospective studies on biorhythmic changes among patients with coronary heart disease, atrial fibrillation, and chronic heart failure. The features of the rhythmic activity of the thyroid gland in cardiovascular pathology are described. In conclusion, the authors indicate that a deeper study of the individual biorhythmic characteristics would help to introduce an additional view of the mechanisms of development and progression of diseases and create prospects for introducing new effective methods of treatment.