This investigation aimed to study the protective effects of moringa (Moringa oleifera L.) and green tea (Camellia sinesis L.) leaves aqueous extracts on hypercholesterolemic rats. Twenty five male albino rats weighing 200±5g were divided into two main groups (5 rats each); the first (5 rats) was control negative group (ve) and fed on basal diet along the experimental period and the second (20 rats) divided into four groups; one fed on basal diet only and the rest three groups fed on basal diet with orally fed with moringa, green tean and mixture extracts of them, respectively, for 28 days, then all food groups fed on 1.5% cholesterol-enriched diet and 10% lamb fats for 21 days. At the end of the experimental period, all rats were mercy sacrificed then blood samples were collected to determine serum total cholesterol, triglycerides, LDL, VLDL, HDL, TP, Alb., Glob., CK, D. Bil., GGT, Fe, Na and Ca. The results revealed that oral adminstration with 5% aqueous extracts of moringa, green tea leaves and mixture of them produced significant decrease in serum total cholesterol, triglycerides, LDL, VLDL, TP, Alb., Glob., CK, D. Bil., GGT, Fe, Na, Ca and significant increase in HDL for all tested groups compared to hypercholesterolemic rats specially for mixture diet indicating synergitic action. It could be concluded that moringa, green tea leaves have protective effects on hypercholesterolemic rats.