Benzo[a]pyrene, B[a]P, is considered as a ubiquitous environmental and food contaminants and a top risk factor in the development of several diseases including hepatotoxicity. Several strategies to fight hepatoxicity and its complications have been proposed, because early discovering, prevention and treatment play a pivotal role in reducing the population burden of hepatotoxicity. Therefore, the present study was designed to determine the potential preventive effects of turmeric (Curcuma longa) rhizome powder (TRP) against hepatotoxicity in rats induced by benzo[a]pyrene. Treatment of animals with B[a]P caused a significant increased (p≤0.05) in AST (105.27%), ALT (59.82%) and ALP (141.34%) compared to normal controls. Supplement Supplementation of the rat diets with TRP (0.25 to 1.0 g/100g w/w) prevented the rise of mean serum AST, ALT and ALP activities. The same behavior was recorded for TBARS level in serum, the biomarkers of oxidative stress in cells and some immunological parameters including albumin levels and protease activity in serum. The opposite direction was recorded for the glutathione fractions (biological macromolecules antioxidant) in serum. These results supported our hypothesis that such functional plant foods powder contains several classes of bioactive compounds with other compounds that are able to prevent or inhibit B[a]P hepatotoxicity through liver serum enzymeslowering activity, decreasing rate on the formation of serum TBARS. Therefore, we recommended TRP by a concentration of 1% to be included in our daily diets, drinks and food products.