Osteoporosis is one of the most common disorders in postmenopausal women, affecting the quality of life and increasing the risk for fractures. This study was carried out to evaluate the effect of diets fortified with sesame seeds (SS) and Soy Protein (SP) on osteoporosis in ovariectomized rats (OVX). Twenty four rats were randomized into 4 equal groups. Group (1) was Control Negative and fed on basal diet, while the other 3 groups OVX-operated. Three weeks after ovariectomy, group (2) was fed on basal diet as a Control Positive, while groups (3) and (4) were fed on experimental diets fortified with the following: (10% SS+50% SP instead of casein, and 10% SS+100% SP instead of casein) respectively for 8weeks. During feeding period, initial and final body weights were recorded. At the end of the experiment, the last 24 hr. urine samples were collected for estimating Ca and P level. Blood samples were collected for estimating serum calcium (Ca), phosphorous (P), alkaline phosphatase (ALP), osteocalcin (OC) levels and estrogen. The uterus were dissected out and weighed. Femur bones also were dissected for Histological examination and DEXA scan. OVX cased a significant increase in the level of serum Ca, P, ALP, OC and decrease Estrogen level .treated OVX rats with fortified diets show an improvement in all previous parameters. Beside that decreased urinary excretion of Ca and P. There were also significant increases in femur bone density in histopathological examination and DEXA scan.