The problem of hyperglycemia has grown to be a significant obstacle for worldwide health issues. Drug resistance to treatments for diabetes and cytotoxicity have caused scientists worldwide to turn their attention from artificial to medicinal herbs. The current investigation aimed to find out how Ivy leaves extract affected the biological markers of diabetic rats. Thirty male adult albino rats (150 ±10 g) were used and divided into five groups (6 rats each). The first group was kept as a negative control group and was given the basal diet, but alloxan injections were given to the other four groups to cause hyperglycemia; the second group was given only a basal diet and served as a positive control group, which as the other three groups received a daily oral dose of ivy leaves extract 50, 100, and 150 mg/kg B.W. The results of treated rats showed a decrease in relative organ weight, liver enzymes, kidney function, serum glucose level, and lipid profile. At the same time, BWG, F.I., FER, and HDL-c were improved by rising compared to the positive control group when ivy leaf extract 50, 100, or 150 mg/kg B.W. was administered orally. The Ivy leaves extract had the best results when used at 150 mg/kg B.W. Conclusion These findings support the extract's traditional usage in the treatment of diabetes by indicating that it contains bioactive substances that can lower persistent hyperglycemia while avoiding complications.

The present study aimed to investigate the effect of Khella Baladi on the amelioration of kidney dysfunction in hyperoxaluric rats. Thirty-six adult male albino rats were divided into six groups, six rats for each. One of them was kept as a (-ve) control group, while the other five groups were treated with ethylene glycol 0.75% and ammonium chloride 1% for a week via the drinking water to induce hyperoxaluria. Khella Baladi was added to five groups in different quantities (1.5, 3, 4.5, and 6%), respectively. The treatment lasted for 28 days. From the obtained results it was showed that treatment with Khella Baladi in different quantities (1.5, 3, 4.5, and 6%), respectively for 28 days caused a significant (P ≤ 0.05) increase in weight gain%, feed intake, feed efficiency ratio, HDLc, total protein, albumin, globulin, and serum (Na & K), but with significant (P ≤ 0.05) decrease in relative organs weights, liver functions, kidney functions, urine (Na &K), serum glucose, serum bilirubin fractions, TC, TG, LDL, and VLDL. The best treatment was for Khella Baladi 6%. Therefore, it can be concluded that Khella Baladi could minimize the hyperoxaluric effect of (NH4Cl+EG) and potent a diuretic effect.