The study aimed to measure the impact of regulation non-financial disclosure on the financial performance of Egyptian banks in light of the information asymmetry. By conducting an applied study on a sample of 28 Egyptian commercial banks, during 7 years from 2013 to 2019, To test the causal relationships between the variables (before/after), the Central Bank obligated banks in 2016 to allocate 20% of the total loan portfolios to finance medium, small and micro enterprises. The results indicated that there is a significant adverse effect of the regulation of non-financial disclosure on the level of information asymmetry, and a significant adverse effect of the level of information asymmetry on the bank's financial performance. And the existence of a significant positive impact of the regulation of non-financial disclosure on financial performance, through the effect of the independent variable on the level of information asymmetry, the results of the study also showed that the discrepancy that occurred in the financial performance of the bank due to the regulation of non-financial disclosure is partly due to the impact of the regulation of non-financial disclosure on the level of information asymmetry.