Given the physiological significance and the need for further physiological and morphological knowledge of the adrenal glands, the objectives of the current study were to compare morphometric data between the right and left adrenals of male squirrels and hamsters. The study was conducted on five squirrel males and five hamster males. The glands in both animals were removed and fixed in neutral formalin solution. It was found that the squirrel contains two brown-colored right and left adrenal glands connected anteriorly and medially to each cranial pole of the kidney, and the right adrenal gland had a longitudinal shape, while the left gland had an oval shape. Hamsters had two pairs of brown adrenal glands located anteriorly attached to each kidney's cranial pole. The right adrenal gland was round in shape, while the left was oval. The statistical results showed a significant difference between the left and right suitable adrenal glands in both animals, as well as a significant difference between the squirrel gland and the hamster gland, where it was found that the right and left squirrel glands are larger more significant, heavier, longer and thicker than the adrenal gland in hamsters after the following measures were adopted: weight, length, thickness, width, and size.