Subacute toxicity of Pluronic F-68, a non -ionic surfactant, was investigated with Wister rats.Three times every other day intraperitoneal injections of Pluronic F-68 at a dose of 1.0, 4.0, 10 or 40 mg/ml produced no gross changes in the kidney and liver.But the fatty granulas were observed in the renal tubules and in liver.In 13 open heart surgery 0.6-1.0 mg/ml of Pluronic F-68 were administered in bypass circuit. Pluronic F-68 was very effective to prevent the hemolysis and no significant harmful side effects were recognized in our series.But special care have to be directed in prolonged extra-corporeal circulation.

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