Ewing sarcoma/primary neuroectodermal tumors are rare, invasive, and small round blue cell tumors. There are few reports of its occurrence in the urinary system. Here, we present the first middle-aged female patient whose Ewing sarcoma primary site was in the ureter. The main clinical manifestation was intermittent hematuria. She was in good health after complete surgical resection and adjuvant radiotherapy. To date, there has been no recurrence or metastasis. Accurate early diagnosis and appropriate treatment can help prolong survival. 18F-fluorodeoxyglucose positron emission tomography/computed tomography is expected to be an effective means of evaluating treatment effects and detecting metastasis and recurrence. In this article, besides introducing a case of Ewing sarcoma/primitive neuroectodermal tumor of the ureter, we review the literature to discuss the current status of diagnosis and treatment.

Glioblastoma multiforme (GBM) is a common brain tumor that rarely metastasizes extra-cranially. We present the case of a 40-year-old male with left temporal GBM who underwent craniotomy followed by radiotherapy and chemotherapy. Postoperative MRI scans at different time intervals demonstrated a good response. Eleven months after the initial diagnosis, there were no clinical or radiological signs suggesting recurrence. However, the tumor showed metastasis simultaneously to the chest wall, lungs, and bone, despite 2 cycles of chemotherapy. The patient developed paraplegia 14 months after the initial diagnosis and died due to systemic failure 19 months after diagnosis. Extracranial metastasis of GBM is extremely rare. We present the unusual case of a patient with GBM who showed simultaneous metastasis to the lungs, bone, and chest wall. The prognosis of patients with extracranial metastasis of glioblastomas is very poor, regardless of chemoradiotherapy. Newer approaches, such as immunotherapy and anti-angiogenic therapy, need to be further studied.