This study was designed to examine the aging effect on bone formation induced by recombinant human BMP-2 (rhBMP-2) combined with polylactate-polyglycolate-copolymer/gelatine sponge complexes ( PGS) at palatal subperiosteal sites (N=72) in 36 Wister strain male rats, at 10 weeks, 30 weeks and 70 weeks of age. The rats at each age were divided into three groups: no implant (CN) , PGS implant alone
The acute phase of periodontitis (periodontal abscess) has been thought to be related with rapid periodontal breakdown. The effects of topical application of 2% minocycline hydrochloride ointment into the periodontal pockets in the acute phase of periodontitis were studied. One hundred patients with acute periodontitis including periodontal abscesses participated in this study. Patients were assigned randomly to either the test or control groups and compared by a blind method. Acute periodontitis including the periodontal abscesses were treated by subgingival irrigation plus application of 2% minocycline hydrochloride (test group) or by subgingival irrigation only (control group) , and examined clinically at baseline, third and seventh days. Microbiological samples were also collected at the baseline and seventh days. The study was performed based on the standards of Good Clinical Practice (GCP) . Though the clinical improvements were observed in both groups after treatment, the test group had better results than the control group. The test group showed better improvement of probing depth and attachment level than the
Bone morphogenetic protein (BMP) may have great benefit in periodontal therapy. The purposes cartilage formation was seen in the BMP-free, 4 jig or 20 jig BMP-combined groups. In the 100 jig BMP-combined group, slight bone formation was observed. In the 500 jig BMP-combined group,
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