1,3-Benzothiazinone derivatives have widely bioactivities. So the methods for the synthesis of these 1,3-benzothiazinone derivatives have attracted enormous attentions worldwide. From the method of introducing sulfur atom and the reaction mechanism for the formation of benzothiazinone derivatives, the method of synthesizing 1,3-benzothiazinone derivatives has been summarized in this review. So the thiophenol derivatives, disulfide derivatives, the same carbon connected with amino and mercapto derivatives, isothiocyanate derivatives and some smaller sulfur molecules are used as starting materials.