Multiplicity fluctuation of the target residues emitted in the interactions in a wide range of projectile energies from 500 A MeV to 60 A GeV is investigated in the framework of two-dimensional scaled factorial moment methodology. The evidence of non-statistical multiplicity fluctuation is found in 16O–AgBr collisions at 60 A GeV, but not in 56Fe–AgBr collisions at 500 A MeV, 84Kr–AgBr collisions at 1.7 A GeV, 16O–AgBr collisions at 3.7 A GeV and 197Au–AgBr collisions at 10.7 A GeV.