Metal-organic framework compound consisting of terephthalic acid and chromium cation (TPA _ Cr) was prepared by the hydrothermal method and characterized by XRD, N2 adsorption-desoprtion isotherm, TGA-DTA and TEM. The prepared TPA _ Cr was crystalline and phase-pure. Noble metal was supported on TPA _ Cr by the conventional impregnation method. The specific Pd salt and solvent for impregnation significantly influenced the location of Pd. With [Pd(NH3)4](NO3)2 dissolved in water, Pd was located in the micropores of TPA _ Cr, whereas with PdCl2 dissolved in water or methanol, Pd was located on the external surface of TPA _ Cr. Hydrogenation of cinnamaldehyde and crotonaldehyde, and cross-coupling between aryl bromides and phenylboronic acid were studied using Pd/TPA _ Cr and Ru/TPA _ Cr prepared as above. Hydrogenation of the two model aldehydes occurred in the micro-and meso-pores of TPA _ Cr whereas cross-coupling reaction of bulkier compounds occurred mostly on the external surface of TPA _ Cr.