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Background: To provide evidence on the global epidemiological situation of neonatal hypothermia and to provide recommendations for future policy and research directions.

We investigated a physiological function by fermenting a medicinal mushroom, (Cudrania tricuspidata fruit). A fermentation using lactic acid bacteria and the extracts isolated from 70% ethanol fractionation was included in cultured mouse spleen cells for cytokine secretion. As a result, total polyphenol content improved by 47% by organic acid fermentation. This was regarded as immune activity in fermented C. tricuspidata fruits, as the levels of interleukin (IL)-2 and IL-4 secretion increased. In addition, when the extracts were treated with a stimulant lipopolysaccharide, the secretion of helper T (Th) 1 cytokines IL-2, IL-12, and tumor necrosis factor-α was suppressed, while the secretion of Th2 cytokines IL-4, IL-5, IL-6, and IL-10 significantly increased. Therefore, this study suggests that fermentative [19,23]. 이러한 면역작용 세포의 활성화를 유도 하기 위하여 기능성 소재로서 면역증진에 기여하고자 상황버 섯의 polysaccharide와 같이 천연물로부터 면역증진활성이 연 구되어 왔다 [16,20,29].

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