Objectives: The OECD QSAR Application Toolbox was developed by the Organisation for Economic Cooperation and Development (OECD) to facilitate the practical use of QSAR approaches in regulatory contexts as well as to reduce the need for additional animal testing. In this study, human health and the ecotoxicity of chemicals were predicted by applying the OECD QSAR Application Toolbox and the results were compared with experimental data in order to evaluate the applicability of this program. Methods: Read-across, trend analysis, and QSAR of OECD QSAR Application Toolbox were used for the prediction of toxicity. Results: The toxicity prediction was conducted on 6,354 chemicals for which toxicity data have been produced on the six endpoints of skin sensitization, skin irritation, eye irritation, mutagenicity, and acute toxicities of fish and Daphnia. From the total of 6,354, we obtained prediction results for 1,621 chemicals (25.5%). Conclusions: The predicted properties of mutagenicity, skin sensitization, and acute aquatic toxicities were reasonably good when compared with experimental data, but other endpoints were not due to the limitation of applicable chemical groups.

There was a plan to develop a low-carbon green village(approximately 400,000m 2) in A city, a new town. Restoration of water cycle is essential for creation of the low-carbon green village. Therefore, installation plan of LID-decentralized rainwater management facilities for natural water cycle was established for creation of the low-carbon green village. Analyses on effect of the water cycle were performed in conditions of before, after developing the low-carbon green village and after installing the LID facilities(rain garden, constructed wetland, rainwater harvesting facility, etc.) using SWMM-LID model developed by EPA. Due to the characteristic of permeable area before development and significant green spaces after development, installation plan of LID facilities to restore the water cycle did not show an obvious effect. However, potential of the hydrological cycle could be seen by the installation of the LID facilities.

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[Purpose] The objective of this study was to examine how 60 minutes of patient education before exercise classes affected promotion of physical activity (PA) among patients with knee pain. [Subjects and Methods] The study design was a single-blind, quasi-randomized controlled trial. The participants were 81 patients (age: >50 years) with knee pain. They were randomly classified into two groups: Ex + Edu (exercise and patient education) and Ex (exercise). Each participant took part in exercise classes and physical therapy for 12 weeks. Those in the Ex + Edu group additionally received 60 minutes of initial patient education before the class. This consisted of a lecture delivered by a physical therapist using a booklet. [Results] Subjective PA showed a relation between the groups, though its effect was small. However, physical function, pain, self-efficacy, pain catastrophizing, and quality of life showed no relation between the groups. [Conclusion] Patient education for 60 minutes before an exercise class was shown to promote PA, but the effect was small. 要旨： 〔目的〕膝痛患者に対する運動教室前の 60 分の患者教育の身体活動（PA）促進効果を検証すること． 〔対象と 方法〕研究デザインは単盲検準ランダム化比較試験とした．対象は，50 歳以上の膝痛患者 81 名であった．参加者を Ex + Edu 群（運動と患者教育）と Ex 群（運動）の 2 群に分類し，両群とも 12 週間の理学療法と運動教室での運動 を実施した．加えて Ex ＋ Edu 群では， 理学療法士が初回の運動教室前に小冊子を用いて 60 分間の患者教育を行った． 〔結果〕主観的な PA は，両群間で交互作用を認めたが効果量は小さかった．しかし，身体機能，疼痛，自己効力感， 痛みの破局化，生活の質は交互作用を認めなかった． 〔結語〕60 分の患者教育の効果は小さいが，PA の促進を認める． キーワード：変形性膝関節症，患者教育，身体活動 1) 福岡リハ整形外科クリニック：福岡県福岡市西区野方 7 丁目 770 番地 （〒 819-8551） TEL 092-812-1555 2) 福岡リハビリテーション病院 リハビリテーション部 3) 福岡大学大学院 スポーツ健康科学研究科 4) 福岡大学 スポーツ科学部 5) 福岡大学 基盤研究機関身体活動研究所 受付日 2017 年 6 月 20 日 受理日 2017 年 7 月 25 日

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